The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Overmethylation and weight gain (MTHFR)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by dominover, Mar 11, 2017.

  1. dominover

    dominover

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    Why is Overmethylation associated with weigh gain and difficulty in losing it? What causes the weight gain and difficulty in losing weight for Overmethylators? Is it linked to low histamine?

    Does anyone understand the process enough to explain it?
    Thanks
     
  2. Valentijn

    Valentijn Senior Member

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    Methylation has been infiltrated by a great deal of quackery, attributing pretty much every symptom imaginable to undermethylation or overmethylation, and sometimes both at the same time. I very much doubt there's any connection with weight gain.
     
  3. dominover

    dominover

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    It may well be.. I'll deduce from that, that there is no connection.
    What makes you think that it's quackery? Did Ray Peat say it?
     
  4. dominover

    dominover

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    No answer? I'm not too surprised!
     
  5. rawcreamqueen

    rawcreamqueen

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    Bath, England
    i do not understand the process but have been overmethylated for a while - i trialed niacin yesterday and after a few doses of 50mg every few hours, my lethargy, dulled brain, negative thoughts went, also my feeling of being a lot heavier went to. i definitely had a heavier bottom half. and i slept really well last night which i hadn't been able to do in about a month. i thought i had low cortisol (had this a few years ago and had to go on daily adrenal support for a couple of years) and had tried adrenal cortex but that didn't help . i am also on NDT for my hypothyroidism and bhrt for my menopause. i wish i knew what was going on but thank god for nicotinic acid. i did not think i was overmethylating as i am not following the protocol at the moment. i did have a very stressful 6 month run up to the end of last year.
     
  6. Carnation4000

    Carnation4000

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    I wonder about this connection too!! Every time I have an overmethylation episode, I gain about a pound. And it doesn't go away no matter how much I exercise or how clean I eat. It is seriously frustrating. I have spent hours and hours researching but no real answers...
     
    dominover likes this.
  7. arewenearlythereyet

    arewenearlythereyet Senior Member

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    I think the main problem is that we don't know enough to make broad sweeping statements like " over methylation causes weight gain". It's too far removed from the end process to attribute definitively attribute cause? It's probably riding on the back of hypothyroidism studies ?

    My test of quackery is to find 5-10 separate pieces of research that points in the same direction. If they exist it's worth looking into further, if not then I'm afraid .......To make it substantive I would like to see clinical research with patient studies, but that isn't always available. I dismiss books as being fiction unless there is clear references to research. Phrases like "it is believed that....." Or " many believe " or "it is thought". Generally can be interpreted as " I don't have any research to back this point up"

    The fact that you can't find anything substantive gives you the answer I think?
     
  8. dominover

    dominover

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    I know how your feel. I slipped into this after a serious bout of stress 10 years ago and haven't been able to lose a pound since.. All thyroid hormones are at optimal levels so I'm stumped. Running 65 km a week and gym have done nothing for my weight. If anything I've got fatter.
     
    Carnation4000 likes this.
  9. dominover

    dominover

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    I agree that there's a lack of evidence out there. Unfortunately without lateral thought we will be waiting forever for the answers we require to become profitable (otherwise who's going to pay for it). I'm a bit of a cynic too so I do require some proof. If I can relate the pseudo science to my on issues in some way or another then I'm getting further than the doctors can get me.

    Thanks for your response.
     
    arewenearlythereyet likes this.
  10. Carnation4000

    Carnation4000

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    That sounds exactly like me....thyroid meds are optimal, and I feel like my exercise (regular weight training and cardio) level is about right. I think inflammation may be the real culprit - sigh...
     
  11. Carnation4000

    Carnation4000

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    So, here's some info to chew on: Oxidative stress and inflammation appear to be closely interlinked in obesity, although it is difficult to establish the temporal sequence of their relationship. Here's the reference - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676851/
     
  12. Basilico

    Basilico Florida

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    My husband is an overmethylator and has been lean and muscular for most of his life.

    He has always been an extremely healthy eater who never eats fast food, fried/junk food, or much in the way of desserts or snacks. He also has been active in sports and weightlifting for most of his life.

    I think eating habits and activity levels are far more important than methylation status.
     
  13. arewenearlythereyet

    arewenearlythereyet Senior Member

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    Completely agree. I wasn't particularly athletic or into fitness, but was strong, had high stamina, was aerobically active and ate a clean balanced diet before I got ill.

    I think the true cause of weight gain for me was the fact that I stopped moving as much and didn't cut down my calories enough. I also think that as my Krebs cycle got screwed up my carb consumption became too high for what I could process and I started laying down more of my carbs as fat. I've lost a bit of the weight by consuming less than 1900 calories per day and reducing my carbs to 100-150g.
     
  14. Tunguska

    Tunguska Senior Member

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    I tried to figure this out a few times but it's impossible to get a clear picture.

    On one hand, histone and DNA methylation factually affects the browning of white adipose tissue and expression of brown adipose tissue (http://www.jbc.org/content/early/2015/08/25/jbc.M115.662650 + several others). Even worse, if some PGC-1α promoters get too methylated it could stop thyroid from working (https://www.ncbi.nlm.nih.gov/pubmed/24622795). (PGC-1α is "the master regulator of mitochondrial biogenesis" in wikipedia's opinion).

    It looks damning but you can't say much about what dietary methyl groups will do in relation to that if anything. The methylation of some other promoters does the exact opposite, those just stand out the most. In articles they mostly blame palmitic acid for everything (figures).

    The closest you get to saying that dietary methyl groups contribute to fat gain is from the liver effects of SAMe:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336596/
    If you increased the export of VLDL and it's malformed on top that has potential to affect fat mass (sure this is NAFLD but I bet you're not flaunting your liver health).

    In a general way liver methylation cycle is tied to liver lipid handling. I don't know the extent to which it happens in other tissues. Maybe someone has better information, but they're not posting it...
     
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  15. Carnation4000

    Carnation4000

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    Will definitely check out the references you mentioned! My weight was holding pretty steady until this methylation nightmare started about a year ago. Thanks!
     

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