Coming off effexor, ive been on b6, zinc and sam-e and thats working well. About to drop it completely as i've halved it the past two months. From what i can assess, effexor is a noradrenaline inhibitor and ssri, so you'd find people respond to it well. The more anxiety you'd experience, the more adrenaline would pump through. I'd also be looking at pyroluria like hixxy.