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Optimization of XMRV and MLV-related virus detection for screening of blood

Discussion in 'XMRV Research and Replication Studies' started by Jemal, Aug 31, 2011.

  1. Jemal

    Jemal Senior Member

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    I think this project gives us more evidence that the XMRV/MLV saga is far from over. I found this project through the NIH project reporter. The project has a start date of 1 august 2011, meaning it's new. The project got $277.000 from the NIH and it's being administered at the National heart, lung and blood institute.

    http://projectreporter.nih.gov/project_info_description.cfm?aid=8178650&icde=0

    Graham Simmons has been involved with more XMRV studies by the way, I suggest you Google him if you are interested.
    redo likes this.
  2. Enid

    Enid Senior Member

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    Nice find - thanks Jemal - the story of these viruses is far from over. Hooray !
  3. eric_s

    eric_s Senior Member

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    Wait, this reminds me of the Blood Working Group. Also i think i've heard the name Graham Simmons in the context of the BWG before. Couldn't this be financing for the Blood Working Group?
  4. Jemal

    Jemal Senior Member

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    Simmons is a member of the BWG. He has also done some other research though, with Abott.
    Not sure if this is BWG related, but it crossed my mind...
  5. eric_s

    eric_s Senior Member

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    A lot of the project description sound like it's about the BWG. Multiple labs, the mixed results, development of an assay, screening of blood donors, determining transmissibility...
  6. Bob

    Bob

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    Very interesting. Thanks Jemal.

    It does seem to be related to the BWG project, doesn't it.
    It might be the next stage of the BWG project, investigating how to efficiently detect XMRV in large numbers of blood samples.

    What's very interesting is that they confirm that they have discovered that XMRV can be detected 'more reliably' if samples are stored at 4[SUP]o[/SUP]C for 2 to 4 days:

    This quote suggests that most, or even all, of the labs ("multiple laboratories") in the BWG are successfully and reliably detecting XMRV, at least in some of the samples.
  7. Jemal

    Jemal Senior Member

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    It's possible... I think the codes for BWG phase III have been broken. As stated in this article:
    http://www.cfscentral.com/2011/08/breaking-codes.html
    Which probably means the results are now known.

    When I first found this project I though it was significant and I still think it is. We should be careful not to read too much into it though. It could be unrelated to the BWG or planned before results were known.
  8. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Surely they would have only bothered to proceed with this project if the results were known? Isn't it wonderful that the money can be found for the right people.

    If the announcement follows the breaking of the codes, then the wording and the timing are significant.

    Why say this? Is this confirmation of the Science study?
  9. Jemal

    Jemal Senior Member

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    Yes, it would be more logical for this project to start after results were known. However:

    - I am not sure if the timing is right, the project has a startdate of 1 august 2011 and officially the results of the BWG were not known back then I think. Although this project could have been started after the results were known of course.
    - It could even be entirely unrelated. We have several government agencies looking at XMRV and they are saying different things (at least the FDA, CDC and NCI). So I wouldn't be surprised if another agency decided to do some more research on their own...

    Anyway, if it's BWG related this could be huge. This could mean labs in the BWG are reliably finding XMRV.

    I don't want to set myself up for a disappointment, though... Simmons has also been involved with some negative studies.
  10. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    I don't think the codes needed to be broken. All that was required was positive tests from multiple labs. Doesn't really matter which labs, which samples. The fact that there was positive samples is the main game. And that has probably been known for a while.
  11. redo

    redo Senior Member

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    +1 Jemal. Nice find.
  12. currer

    currer Senior Member

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    Well done finding this jemal.
  13. Firestormm

    Firestormm Guest

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    Is this not about screening the blood supply? We knew this was planned didn't we: 20 January 2011: WSJ: http://blogs.wsj.com/health/2011/01/20/xmrv-testing-the-blood-supply/

    Noone doubts that XMRV is a retrovirus. So they were always going to try and screen the blood supply even as a precaution to see if it can be done en-masse as it were.

    If XMRV (as indeed any other pathogen) is found to be in human blood and is at some later stage found to be an active contributor to 'human disease' then they will be ready to reject (presumably) any blood as if it were HIV for example.

    Will have another read of the submission but am fairly sure this is where they are coming from...

    Layman speaking as opposed to dead-man walking :)
  14. Firestormm

    Firestormm Guest

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    Yes I believe this was the other relevant article at the time: http://online.wsj.com/article/SB10001424052748704243904575630700111729446.html

    Still is this latest study going about looking for 'XMRV' in the 'right' way? Depending on what you believe about this retrovirus of course. Is looking for it in blood correct? I guess only time will tell and if BWG and Lipkin prove inconclusive or outright negative - then will this be the end or merely another interlude? What will happen to this search for a mass test? What if this search can't find 'XMRV'?

    Questions questions questions... always will be questions I suppose.
  15. liquid sky

    liquid sky Senior Member

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    Sounds like they are definitely finding XMRV in multiple labs in both plasma and PBMCs. That is good news. Now they are trying to find a faster, reliable test. Whoever comes up with that test will be set up to make billions. I am sure many are trying to be the first.

    The contamination of the blood supply has been the ticket to finally get this disease finally studied and validated. Treatment will flow from that point. Whether it is part of the blood working group or not doesn't matter. What matters is they still see a need for a fast test to screen the blood supply as of just 1 month ago.
  16. Bob

    Bob

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    I think that sums up XMRV perfectly!!!
  17. Jemal

    Jemal Senior Member

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    I just hope the "multiple labs are finding XMRV" is not old news... like from months ago. The project is new, but who knows when the description was created.

    Oh, and for anyone who might have missed it. This thread contains some more information about XMRV that I found mighty interesting:
    http://forums.phoenixrising.me/show...-and-therapeutic-treatment-of-prostate-cancer
  18. eric_s

    eric_s Senior Member

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    When i read the part about "multiple labs" i thought it might refer to the BWG phase II (i think it was II b, to be exact). But i don't know for sure either.

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