Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
Simon McGrath provides a patient-friendly version of a peer-reviewed paper which highlights some of the most promising biomedical research on ME/CFS ...
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opioids (from gluten & dairy), genes, pain & immunity

Discussion in 'Pain and Inflammation' started by ebethc, Apr 19, 2015.

  1. ebethc

    ebethc Senior Member

    I have 2 bad copies of the snp rs1799971 from gene OPRM1, which affects opiate receptors. I'm wondering if this may be 1 of the keys to my constant pain..... I've also been reading about the opiates in dairy & gluten (casomorphin, gliadorphin) and am wondering if there's a relationship between reacting badly to dairy & gluten if you have OPRM1 mutations....

    1. If you have this gene, is it best to avoid gluten & dairy?
    the obvious answer is, well, try it and see! but I'm more interested in understanding the mechanism of action.

    2. re Immunity: I'm also wondering if there's a link between opioid function and immunity. does anyone here have any first-hand knowledge?

    I have experimented w LDN off & on.. I like it, but feel like it hasn't taken full effect because I have other issues... I just started it again, and I know that it's supposed to work better if you give up gluten & dairy... i'd like to understand the mechanics w LDN - Gluten/Dairy better if anyone can explain it to me... why do you have to give up Gluten & Dairy for it to work better??

    Interesting article re interplay btwn opioid receptors & viruses:

    Opioid receptors control viral replication in the airways

    Some notes from gluten & casein:
    The peptides from gluten and casein are important because they react with opiate receptors in the brain, thus mimicking the effects of opiate drugs like heroin and morphine. These compounds have been shown to react with the brain's temporal lobes that are involved in speech and auditory integration.
    oceiv likes this.
  2. Valentijn

    Valentijn Senior Member

    A meta-analysis shows that there's no consistent association between that SNP and substance dependence:

    They might find more convincing evidence at some point in the future, but for now it's looking like a false alarm. This happens pretty often with research involving SNPs.
    ebethc likes this.

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