Looking Ahead to Change: Little by Little
I don't make New Year's Resolutions. I don't think I ever really did, but the last decade or two would have been enough to stifle that impulse. I've just been too aware that I don't have that much control over what happens in my life.
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Opinions on de Meirlier

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by neweimear, Sep 15, 2017.

  1. justy

    justy Donate Advocate Demonstrate

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    Anyone with a known tick bie and M.E should probably jiust get treatment with an ILADS Dr IMHO
     
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  2. neweimear

    neweimear Senior Member

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    I dont have a known tickbite
     
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  3. neweimear

    neweimear Senior Member

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    Mel, I never recall a tick bite and I have no pain so that is why I query my weak positive result. Does lyme cause pain in most people? Thank you.
     
  4. Mel9

    Mel9 Senior Member

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    It certainly did in my case
     
  5. Orla

    Orla Senior Member

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    barbc56 and neweimear like this.
  6. Banana94

    Banana94

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    There are some reasons treating the gut with ABX like if you have SIBO and other things. He treated me 2 months with Azithromycin and now 3 month Xifaxan( poorly Absorbed). I feel no changes, only the No carb diet really helps me. I dont know if i can trust him but I take the Xifaxan for 2 more month because I tolerate it well. If he prescribes me more ABX after 5 months I will stop taking it. The risk to destroy the gut is to high...
    And (!) All my markers for leaky gut are negative, but I have digestion problems for all my life...
     
    ljimbo423 likes this.
  7. barbc56

    barbc56 Senior Member

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    KDM has tests for leaky gut. This is just one example of his lack of science and why I don’t trust him as leaky gut is a made up health condition with an unvalidated test. If you are diagnosed with LG, then the appropriate diagnosis and treatment needed is missing and this could cause serious harm.
    https://sciencebasedmedicine.org/leaky-bowel/
     
  8. unicorn7

    unicorn7

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    https://www.thedailybeast.com/new-r...-is-real-may-be-the-cause-of-several-diseases

    I have found a lot of articles about leaky gut ( look for hyperpermeable bowel) on pubmed, there has been some research on it in ME/Cfs as well.

    Other than that, there is a lot of research going on in the microbiome area and Maureen Hanson mentions leaky gut in her presentations as well. She did some research on biomarkers like LPS and CD14.

    I’m not too keen on antibiotics, but rifaximine is not absorbed, so it only works in the gut. Resarch has shown that is only works in the small intestine and that it doesn’t lead to antibiotics-resistance in the bacteria of the colon.

    Seems to me that it is a pretty safe option. For me, it works extremely well. Got rid of all my bowel problems, my inflammation markers are going down and I’m feeling a lot better.
     
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  9. justy

    justy Donate Advocate Demonstrate

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    Intestinal permeability however and bacterial translocation, is what KDM diagnosed me with. These are just the correct terms. When KDM uses the term Leaky gut, he most likely is saying that as a way for a lay person to undertsand intestinal permeability. If you see this research on Liver function, you can see intestinal permeability and bacterial translocation is a validated diagnosis, which is believed to cause all manner of health issues

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451427/


    It was discovered not that long ago, that Zonulin had a role to play in intestinal permeability - being increased in people who show problems with the tight junctions in the gut

    https://www.ncbi.nlm.nih.gov/pubmed/21248165

    In turn we can see that KDM uses a stool test to check for levels of Zonulin, which may indicate intestinal permeability

    I had the above test done and it showed high levels of IGM against a variety of gut microbes in my blood stream. Bcaterial translocation is a known medical issue.

    http://www.redlabs.be/ida

    Do note that 'leaky gut' is used in quotation marks to show its colloquial use for intestinal permeability etc.
     
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  10. Learner1

    Learner1 Professional Patient

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    As stated before, sciencebasedmedicine is not a credible source of medical information. The folks who run it seem to be highly educated, arrogant jerks with their heads stuck firmly in the sand, with zero interest in helping any of us. They pan many issues, diagnostics, and treatments that may be quite beneficial for many of us.

    The integrity of the intestines and microbiome are well recognized by leading medical institutions as important underpinnings to health:

    https://www.webmd.com/digestive-disorders/features/leaky-gut-syndrome

    https://www.nutritionletter.tufts.e...articles/The-Lowdown-on-Leaky-Gut_2239-1.html

    And see attached, which gives a detailed description.
     

    Attached Files:

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  11. msf

    msf Senior Member

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    It was really kind of you to do all that research for barbc56
     
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  12. ljimbo423

    ljimbo423 Senior Member

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    Here is Maureen Hanson's study on the gut microbiome and intestinal permeability in CFS from June 2016-



    Results

    We observed elevated levels of some blood markers for microbial translocation in ME/CFS patients; levels of LPS, LBP, and sCD14 were elevated in ME/CFS subjects.

    Levels of LBP correlated with LPS and sCD14 and LPS levels correlated with sCD14. Through deep sequencing of bacterial rRNA markers, we identified differences between the gut microbiomes of healthy individuals and patients with ME/CFS.

    We observed that bacterial diversity was decreased in the ME/CFS specimens compared to controls, in particular, a reduction in the relative abundance and diversity of members belonging to the Firmicutes phylum.

    In the patient cohort, we find less diversity as well as increases in specific species often reported to be pro-inflammatory species and reduction in species frequently described as anti-inflammatory.

    Using a machine learning approach trained on the data obtained from 16S rRNA and inflammatory markers, individuals were classified correctly as ME/CFS with a cross-validation accuracy of 82.93 %.

    Conclusions
    Our results indicate dysbiosis of the gut microbiota in this disease and further suggest an increased incidence of microbial translocation, which may play a role in inflammatory symptoms in ME/CFS.
    https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0171-4


    Jim
     
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  13. Nickster

    Nickster Senior Member

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    @Learner1 you are right on with the fact that the current medical community does not know anything about this disease and they don't seem to want to branch out to figure it out. So we need to be skeptical with their findings and recommendations.

    It takes a person who specializes in this or willing to think outside of the box that we can somewhat rely on. It's tough to find.

    We are riding a covered wagon into the new frontier of medicine. It's hard.
     
  14. justy

    justy Donate Advocate Demonstrate

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    Hhah - you crack me up. Im here to help, where i can ;)
     
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  15. justy

    justy Donate Advocate Demonstrate

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    Thanks, Jim for this,

    KDM also tests for LPS and sCD14 - he also considers these markers for microbial translocation, so clearly he and Maureen Hanson are in accordance with this.
     
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  16. keenly

    keenly Senior Member

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    That site is ran by crooks who know nothing. That site has received funding from COCA COLA in the past. They are con men who do nothing but bash supplements, organic food and they promote GMO food.
     
    Last edited by a moderator: Nov 19, 2017 at 11:41 AM
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  17. keenly

    keenly Senior Member

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    Yep. I have had direct run ins with them in the past. They are crooks. They literally promote statin drugs and one of them has written articles saying Organic food should be banned. Madness. Clearly those they serve profit from pesticides. Nobody should pay any attention to their crappy articles.
     
  18. Binkie4

    Binkie4 Senior Member

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    Hi Justy
    I have only just seen your reply. Thanks. What is an ILADS doctor please? I had almost decided to pay for a western blot but gp discouraged me.
    I do need the heart surgery soon, complex according to surgeon. Waiting for test dates. Will probably wait till after that but have no idea about ILADS. Have only started to look up Lyme this year. I have a number of comorbidities, non ME, so I have a lot of doctors but not ME related so a bit behind on the theory so ILaDS
    Could you just say a bit more @justy
     
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