Hi @caledonia and All, My name is Farouk, and I have been lurking on this website for quite some time. I did Dr. Richard Van Konynenburg’s Simplified Methylation Protocol with the addition of one other supplement, called acetyl-l-carnitine (which helped me get out of bed aha); I stayed on the protocol for a year and a half. To be exact, I started in Oct ’12, and I did no 23andme testing (or anything of the sort) so, I sort of just did the protocol blindsided. Prior, to starting the protocol, I had constant headaches, and no matter what I tried, it just would not go away, then within 8 weeks of starting the protocol, I realised that my headaches were longer constant – I still had brain fog, and all the other symptoms of CFS but, it was somewhat almost tolerable. Now, we fast-forward a year and a half later to January 2014, and I have now relapsed. I did not relapse because of Dr. Rich’s protocol but I believe I relapsed because I took a supplement called Biotec Extra Energy Enzymes. I took that supplement for about a week, and then suddenly, I felt a pain in my body that I had never felt in my life, and the constant headaches returned so, I discontinued the supplementation of the Biotec Extra Energy Enzymes. After a week of discontinuing the Biotec supplements, the extreme body pain wore off but the constant headache still has not subsided. For months, I was clueless as to why the Biotec supplement caused me the relapse but, as I stumbled upon the idea of genetic mutations (thanks to Caledonia’s Methylation videos), I hopped onto the Heartfixer website, and read about the CBS mutation, and how it can potentially create excess ammonia and have difficulties converting sulfites to sulfates. Then when I read that MSM, Glutathione, and NAC supplements are really high in sulfur and should be avoided if an individual has an CBS mutation, I was like “Oh, yeah, the Biotec supplements contained glutathione. Hmm, I may have an CBS mutation, and by taking those Biotec supplements, it must have added to the excess sulfur pool”. I decided it was time to finally do the 23andme testing so, I ordered the kit about a month ago, and sent the saliva sample back to 23andme days after the receiving the kit, and received the results for the test about a week ago. I processed the raw data through Geneticgenie (thanks Geneticgenie) – and low, and behold, I am heterozygous for the CBS mutation C699T (though, it is not a rare mutation, it just proves my point with my suspicion of having a CBS mutation… tehehe). Now, I want to start the CBS protocol by going low-thiol instead of low sulfur (and of course, with the supplements Dr. Yasko/Heartfixer suggest, which are molybdenum, yucca, hydroxocobalamin and weekly charcoal flushes). There is one thing I am unsure of, I am also heterozygous for the BHMT-08 mutation. Apparently, the work around for this mutation is to supplement with phosphatidylcholine but, is this done during the CBS protocol or after the CBS issues have been addressed? Because, I have sort of already started supplementing for the BHMT mutation using Now’s Sunflower Lecithin (as GMO is a no-no for moi) about 2 weeks ago I will also attach a screenshot of my SNPs too ☺ Kind regards, Farouk.