1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
ME/CFS: A disease at war with itself
We can all agree that ME/CFS is a nasty disease, particularly in its severe form, but there are abundant nasty diseases in the world. What is unique and particularly confounding about our disease is that so much controversy surrounds it, and not only surrounds it, but invades it too.
Discuss the article on the Forums.

On Life, Liberty and the Pursuit of Hot Chicks

Discussion in 'General ME/CFS Discussion' started by nanonug, Apr 2, 2013.

  1. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    384
    Virginia, USA
    UPDATE:

    Saw my endocrinologist doctor today - just came back from the appointment. She thinks that the toxoplasmosis may very well be the root cause of my health issues. She ordered some additional blood tests (which I did right there at her clinic) and gave me a prescription for a head/neck MRI, which I'll have done next Thursday.

    Waiting for my infectious disease specialist appointment tomorrow morning...

    Things are moving, just the way I like it!
    jeffrez and Valentijn like this.
  2. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    3,230
    Likes:
    3,631
    Cornwall, UK
    I guess it's possibly an indication of that. I had assumed that the benefits were just due to their anticholinergic activity: relaxing muscles, thus reducing tremor and tension, reducing anxiety/adrenaline symptoms and also reducing nausea. I don't seem to get any benefit from the non-sedating, non-anticholinergic antihistamines, although some people say they do.
  3. adreno

    adreno 3% neanderthal

    Messages:
    2,245
    Likes:
    1,346
    Tundras of Europa
    Well, nano says he is looking to enhance activity at the nAChR7. The anticholinergic effects of (some) antihistamines are anti-muscarinergic, rather than anti-nicotinergic, so this will have no effect on the matter at hand in any case.
    nanonug likes this.
  4. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    384
    Virginia, USA
    Well, I don't know what the answer to your question is. However, here's some food for thought: cholinergic anti-inflammatory pathway. Nicotine is known to have some anti-inflammatory properties and this might be the reason, via the nicotinic acetylcholine receptors.
  5. OverTheHills

    OverTheHills

    Messages:
    278
    Likes:
    184
    New Zealand
    Hi
    I am thinking about trying a nicotine patch for improved (hopefully) mental focus/stamina. Does anyone know whether you know pretty quickly whether they are going to help/do nothing/give big side effects??? Like within a couple of days. I wouldn't want to get addicted to nicotine to no purpose.
    Thanks
    OTH
    nanonug likes this.
  6. adreno

    adreno 3% neanderthal

    Messages:
    2,245
    Likes:
    1,346
    Tundras of Europa
    It will work pretty quickly. Within an hour or so.
    nanonug likes this.
  7. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    3,230
    Likes:
    3,631
    Cornwall, UK
    Ah - had forgotten about the different receptor types and not realised that antihists were so specific.
  8. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    384
    Virginia, USA
    In my case, in 30 minutes I am feelin' it!
  9. OverTheHills

    OverTheHills

    Messages:
    278
    Likes:
    184
    New Zealand
    Thanks Nano and Adreno, you handsome devils.
    So looks like I can buy a small pack of patches for an experiment next weekend without fear of developing a drug habit. Goody good.
    OTH
  10. Ema

    Ema Senior Member

    Messages:
    3,187
    Likes:
    3,330
    Midwest USA
    I miss nicotine patches. They did make me feel better!

    I'm looking forward to the galantamine report too.
  11. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    384
    Virginia, USA
    Give me a few days as I am slowly ramping up the dosage until I get to 16mg/day, 4mg at a time... :)
  12. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    384
    Virginia, USA
    Well, thank you! :)

    As an aside, I have been taking Wellbutrin XL 300mg for roughly 6 months now. I stopped the nicotine patches for 2 weeks or so and I felt absolute no withdrawal symptoms! Wellbutrin is definitely a wonderful anti-addiction drug, among other things.
  13. adreno

    adreno 3% neanderthal

    Messages:
    2,245
    Likes:
    1,346
    Tundras of Europa
    Why would you use this, as it is a nicotinic antagonist? It even blocks nAChR7, albeit mildly:
    http://www.ncbi.nlm.nih.gov/pubmed/10991997
  14. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    384
    Virginia, USA
    UPDATE:

    My appointment with the infectious disease specialist yesterday was essentially a disappointment. He apparently does everything based on "guidelines" and currently they say that "asymptomatic" toxoplasmosis causes no problems at all.

    The problem with the current but outdated guidelines is that they ignore the last decade of research indicating that "asymptomatic" toxoplasmosis is far from harmless. "Asymptomatic" toxoplasmosis induces biochemical changes in the brain leading to diseases or disorders as "benign" as schizophrenia, anxiety, depression, increased suicidal risk, Parkinson's, Alzheimer's, migraines and obsessive-compulsive disorder. Yeah, nothing to worry about!

    The saving grace is that he is willing to point me in the direction of doctors that have a more aggressive attitude towards infectious agents so he's not a total loss!
    PennyIA, Valentijn and Xandoff like this.
  15. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    384
    Virginia, USA
    Yes, you have a point and that question has indeed crossed my mind!

    While I started taking Wellbutrin 6 or so months ago, I only found out about T. gondii a couple weeks ago. At this point, I don't want to be making too many changes as I'll have no way of knowing what the heck is working or not. I can tell you however that I lost some needed 30 pounds since starting Wellbutrin and this is not easy to discount. Once things stabilize, however, I will reevaluate the need for Wellbutrin. (Hopefully, galantamine will be able to punch through bupropion's blockade...)
    Xandoff likes this.
  16. mellster

    mellster Marco

    Messages:
    799
    Likes:
    178
    San Francisco
    TG is known to cause chronic problems in some and also to cause long bouts (3+ months) of complete exhaustion and other symptoms. It's one of the pathogens tested for in the delayed Montoya study. It also can cause chronic lymphatic issues. Good find, hopefully it will resolve now.
    nanonug likes this.
  17. Boz86

    Boz86

    Messages:
    8
    Likes:
    1
    Sydney, Australia
    Any updates nanonug? Curious if this route yielded any results for you.
  18. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

    Messages:
    2,396
    Likes:
    1,730
    Midwest, USA
    @nanonug, Are you around anymore?
  19. Sushi

    Sushi Moderator and Senior Member Albuquerque

    Messages:
    6,577
    Likes:
    5,347
    Albuquerque
    Nanonug has not been here since August 3, 2013--you can check the profile page for this.

    Sushi
    Little Bluestem likes this.

See more popular forum discussions.

Share This Page