The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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OMF update....CDR suggested to be implicated in M.E

Discussion in 'General ME/CFS News' started by Ben H, Jun 11, 2016.

  1. Ben H

    Ben H OMF Correspondent

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    Hi guys,

    Checked up on the OMF website and saw this short article:

    http://www.openmedicinefoundation.org/expanded-mecfs-metabolomics-study/

    (Mods feel free to embed)

    The CDR mechanism has been suggested as a model of disease by Dr Naviaux in his recent paper, however this is the first I have read of it actually being implicated in M.E by lab findings!!

    Specifically:

    "Dr. Naviaux completed an initial study of 90 participants (both healthy controls and patients) that showed abnormal metabolites in patients. The abnormalities indicate the mitochondria is in hypometabolism due to a chronic cell danger response state in ME/CFS patients."


    Seriously exciting stuff! For more information on CDR here is a link to Dr Naviaux's paper

    http://www.sciencedirect.com/science/article/pii/S1567724913002390



    B
     
    Last edited: Jun 11, 2016
  2. NL93

    NL93 Senior Member

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    Exciting! I'd love to see the data from the first study.
     
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  3. Ben H

    Ben H OMF Correspondent

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    Too right!!
     
  4. Riley

    Riley Senior Member

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    I wonder if the 90 patient study will be published?
     
  5. RL_sparky

    RL_sparky Senior Member

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    Dr. Robert Naviaux and I have submitted for publication a study, now under peer review and expected to be published in the fall of 2016, looking at 450 metabolites in 43 people with CFIDS/ME and 43 age and sex matched controls. We found a characteristic chemical signature differentiating the patients from the controls. We just received a grant, that along with donations to our newly established non-profit, will allow us to replicate this study.

    http://www.gordonmedical.com/unrave...unding-replication-study-on-cfidsme-findings/
     
  6. Sasha

    Sasha Fine, thank you

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    Is that mitochodrion in the diagram crying? :cry::eek:
     
  7. Sasha

    Sasha Fine, thank you

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    Is it significant that viruses aren't listed on that diagram as a possible trigger of CDR? There are fungi and bacteria and parasites, but not viruses.
     
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  8. Sasha

    Sasha Fine, thank you

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    :woot::woot::woot:
     
  9. Sasha

    Sasha Fine, thank you

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  10. Ben H

    Ben H OMF Correspondent

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    I thought this too @Sasha, but guessed it was probably a misnomer.

    So I checked in the actual paper, and it says "Common microbial threats are viruses, bacteria, fungi, and parasites" eliciting the CDR response.

    So nope, it's just been missed out on the diagram for whatever reason. CDR definitely involves viruses.


    Thus it potentially explains a huge amount!


    B
     
  11. trails

    trails Senior Member

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    Can anyone see a way to tie in the apparent success that Fluge and Mella have had with Rituximab with these latest findings from Naviaux and Davis?
     
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  12. aimossy

    aimossy Senior Member

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  13. Riley

    Riley Senior Member

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    Just off the top of my layman's head, wiping out B cells could lead to a cessation of the CDR response that is possibly causing mitochondria dysfunction in patients.
     
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  14. Scarecrow

    Scarecrow Revolting Peasant

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    Autoantibodies to receptors on mitochondrial membranes?

    Or autoantibodies to anything that has the ultimate effect of promoting the CDR.
     
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  15. duncan

    duncan Senior Member

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    I wonder if most of the cohort were recruited from California.

    Wouldn't be interesting if a single vector could deliver each of those pathogens, either individually or in aggregate?
     
    Last edited: Jun 11, 2016
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  16. A.B.

    A.B. Senior Member

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    Different possibilities:

    1. The subset that responds to Rituximab doesn't necessarily have any overlap with the CDR subset.
    2. Autimmune processes can induce and maintain CDR, either indirectly through disturbance of homeostasis or directly by damaging the cell or directly interfering with its function.
    3. The thing that causes CDR also causes autoimmunity.

    If I had to pick one it would be number two. CDR seems to be a nonspecific response to many different things, which probably includes autoimmune processes of sufficient severity.
     
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