@Valentijn , I think we have to wait for a definite result of the genetic investigations as the final result might not be about the mithochondrias primarily. We´ll see, hopefully in a near future.
I have had severe muscle weakness, low endurance adn PEM for a long time, probably due to an ongoing Lyme infection, but I´m also fulfilling the criterias for a ME-diagnose. To my surprise, all the symptoms that are connected to affected mitochondrias have disappeared when, during shorter periods, the Lyme treatment has been successful. That happened after many IV treatments with antibiotics (even antibiotics that are known to affect the mitochondrias negatively). Unfortunately the bacterias grew back, and they have still not been erradicated, and all my symptoms related to the mitochondrias are back again.
My single-case story, and many others that I´ve read, indicates for me that the mitochondrial issues are caused by something up-streams. The immune systeme would be a good guess, I think.
Naviaux, emphasizes in his articles that infections of any kind are triggering mitochondrial problems so we´ll see what the research results will show. Mitochondrial supplements have helped me as well, but I assume that´s only a symptomatic treatment. Exciting times with all the research results ahead in a not too far future!
I have had severe muscle weakness, low endurance adn PEM for a long time, probably due to an ongoing Lyme infection, but I´m also fulfilling the criterias for a ME-diagnose. To my surprise, all the symptoms that are connected to affected mitochondrias have disappeared when, during shorter periods, the Lyme treatment has been successful. That happened after many IV treatments with antibiotics (even antibiotics that are known to affect the mitochondrias negatively). Unfortunately the bacterias grew back, and they have still not been erradicated, and all my symptoms related to the mitochondrias are back again.
My single-case story, and many others that I´ve read, indicates for me that the mitochondrial issues are caused by something up-streams. The immune systeme would be a good guess, I think.
Naviaux, emphasizes in his articles that infections of any kind are triggering mitochondrial problems so we´ll see what the research results will show. Mitochondrial supplements have helped me as well, but I assume that´s only a symptomatic treatment. Exciting times with all the research results ahead in a not too far future!
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