Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

OMF: New Metabolomics Study Begins (Davis, Naviaux)

Discussion in 'General ME/CFS News' started by mango, May 18, 2016.

  1. mango

    mango Senior Member

    Messages:
    905
    Likes:
    4,979
    http://www.openmedicinefoundation.org/2016/05/17/new-metabolomics-study-begins/
     
  2. A.B.

    A.B. Senior Member

    Messages:
    3,751
    Likes:
    23,193
    Sounds good. Both the biomarker candidate, and the validation study being launched immediately.
     
    Marky90, PennyIA, Mary and 8 others like this.
  3. Bob

    Bob

    Messages:
    9,844
    Likes:
    33,947
    England (south coast)
    Plenty of interesting and hopeful info in the newsletter! :thumbsup::thumbsup::thumbsup:
     
    Johannawj, Marky90, Comet and 3 others like this.
  4. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

    Messages:
    957
    Likes:
    3,953
    Bring it on, Dr. Naviaux!
     
    Johannawj, PennyIA, JaimeS and 5 others like this.
  5. Sidereal

    Sidereal Senior Member

    Messages:
    3,097
    Likes:
    17,177
    Extremely exciting.
     
  6. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

    Messages:
    957
    Likes:
    3,953
    Imagine a treatment that just flips a switch, and boom, you're back to your old fully capable self! OMG!!!
     
  7. NL93

    NL93 Senior Member

    Messages:
    140
    Likes:
    851
    The Netherlands
    Maybe i am just in denial, but i really believe it's possible. Natural remissions happen all the time, so the human body is capable of recovering from this.
     
    KristenSF, Chezboo, Comet and 3 others like this.
  8. JaimeS

    JaimeS Senior Member

    Messages:
    3,205
    Likes:
    11,822
    Mid-Ohio Valley, United States
    I can barely dream of something like that!

    Piece will be on #MEAction tomorrow AM. This is the best news we've had in a long while.

    Did you guys see that someone donated nearly half a million dollars to fund this? One. Person. Or entity, but still. Whoever you are, thank you so much.
     
    Last edited: May 18, 2016
    rosie26, Sean, Johannawj and 8 others like this.
  9. Sasha

    Sasha Fine, thank you

    Messages:
    12,789
    Likes:
    34,216
    UK
    An entity? :nervous::eek:

    Seriously, gigantic thanks to whoever donated it! :bouquet: :balloons::heart:
     
    M Paine, Sean, Johannawj and 10 others like this.
  10. JaimeS

    JaimeS Senior Member

    Messages:
    3,205
    Likes:
    11,822
    Mid-Ohio Valley, United States
    LOLOL an organization! Not :sluggish:!
     
    Sidereal, Comet, NL93 and 1 other person like this.
  11. Sasha

    Sasha Fine, thank you

    Messages:
    12,789
    Likes:
    34,216
    UK
    You never know! Could be a rich :alien: or anything!
     
    JaimeS, Comet and mango like this.
  12. msf

    msf Senior Member

    Messages:
    3,197
    Likes:
    4,484
    I really feel like they should give us the first letter of the metabolite so we can have some fun guessing in the meantime.

    A...apple!
     
    JaimeS, Bob and Comet like this.
  13. Sasha

    Sasha Fine, thank you

    Messages:
    12,789
    Likes:
    34,216
    UK
    It says "a chemical signature" so maybe it's more than one?

    I've absolutely no idea what I'm talking about, though. :)
     
    JaimeS likes this.
  14. msf

    msf Senior Member

    Messages:
    3,197
    Likes:
    4,484
    They definitely could have given us the first letter of one of them then.
     
    JaimeS likes this.
  15. Comet

    Comet I'm Not Imaginary

    Messages:
    675
    Likes:
    3,619
    No letters, damn it! :p ;) :rofl: We might wind up with an acronym... :nervous:
     
    Hutan, Sean, JaimeS and 1 other person like this.
  16. Scarecrow

    Scarecrow Revolting Peasant

    Messages:
    1,903
    Likes:
    5,384
    Scotland
    I've read about Naviaux's cell danger response theory before but didn't realise that the mitochondria were so deeply implicated.
    See also:
     
  17. BurnA

    BurnA Senior Member

    Messages:
    2,086
    Likes:
    9,863
    Didn't we play that game with the lipkin study - was that related to this in any way ?
     
  18. Scarecrow

    Scarecrow Revolting Peasant

    Messages:
    1,903
    Likes:
    5,384
    Scotland
    Don't think it's related in any way - Lipkin / Hornig collaborate with the Simmaron Research Foundation, which is where Lipkin disclosed that they had evidence of altered levels of two metabolites and one immune protein. Will the OMF replicate the findings? :nervous:
     
    Sasha, JaimeS and BurnA like this.
  19. ScottTriGuy

    ScottTriGuy Stop the harm. Start the research and treatment.

    Messages:
    1,089
    Likes:
    4,398
    Toronto, Canada
    I concur.

    I recovered from my first 2 bouts (8 mos and then 2 months) of ME. This third bout has been almost 18 months, but I still believe (most days) that I will recover and get back to my life.
     
    TiredSam, JaimeS and BurnA like this.
  20. JaimeS

    JaimeS Senior Member

    Messages:
    3,205
    Likes:
    11,822
    Mid-Ohio Valley, United States
    Whut.

    I've never heard that mitochondria were involved in cellular defense in any way, shape or form. I *taught* this, and while I went beyond "powerhouse of the cell" simplicity, I never had any idea that mitos did this.

    Anyway, if one goes by the review article @Scarecrow links, Naviaux's premise is that the metabolites that are dysfunctional are 'p' for 'purines'... purine metabolism is wonky. Purines are adenine and guanine -- the adenine that's the 'a' in ATP.

    Significant shifting of the layout, but no words were altered (maybe I removed an 'and'.)

    [​IMG]
    (This is Figure 1.)

    I'm tired, but I'm really sick tonight, so, yeah. I had the time to do this. :ill::sleep: <--- latter one is in my imagination.
     
    Valentijn, TiredSam and Scarecrow like this.

See more popular forum discussions.

Share This Page