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Old snp to new snp changed variant?

Discussion in 'Genetic Testing and SNPs' started by Paralee, Aug 12, 2017.

  1. Paralee

    Paralee Senior Member

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    I was checking out an old snp and it changed to another snp so I checked it out and it shows a different variant. What do you do when this happens? Go with the new one? Thanks
     
  2. Valentijn

    Valentijn Senior Member

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    Which SNPs are they?
     
  3. Paralee

    Paralee Senior Member

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    @Valentijn , it was from an old list from 23andme and it was in the list of '#Differences between user's SNP calls and the rCRS'.....'MT, rs41400048, 250, C, T, the C is mine and the T is the ancestral. I found the one it had been incorporated with rs1116836 but it has a different variant. I'm having trouble with all those old snps, the ones I've tried don't come up in 23andme any more.
    Evidently the whole snp set up is going to change this year, I wonder what 23andme will do.
     
  4. Valentijn

    Valentijn Senior Member

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    @Paralee - rs1116836 isn't the new version of the same SNP. It's on an entirely different chromosome. rs41400048 doesn't exist as an rs number anymore, but that SNP probably isn't problematic, since it's not on a gene.
     
  5. Paralee

    Paralee Senior Member

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    @Valentijn , evidently a lot were replaced, incorporated or deleted in Nov, 2015. I hope they didn't have info I needed, but the enormity of checking each snp is beyond me, anyway. At least I have a little headway with your program but it's still out of my league.
    They are fixing to rename our snps, aren't they? I get the feeling when things are changed starting September, 2017 our rs #'s are going to change to other numbers because of advancements in identifying more genes, etc.
     
  6. Valentijn

    Valentijn Senior Member

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    rs numbers are from dbSNP, so 23andMe can't change them. It's also unlikely that dbSNP will change any that aren't errors.
     
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  7. Paralee

    Paralee Senior Member

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    Thank you @Valentijn , I sure feel better. I haven't learned this stuff yet, thought I was going to have to swing into something completely different.
     
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