1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
ME/CFS: A disease at war with itself
We can all agree that ME/CFS is a nasty disease, particularly in its severe form, but there are abundant nasty diseases in the world. What is unique and particularly confounding about our disease is that so much controversy surrounds it, and not only surrounds it, but invades it too.
Discuss the article on the Forums.

Old post on immune abnormalities in xmrv +

Discussion in 'XMRV Testing, Treatment and Transmission' started by heapsreal, May 13, 2011.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,164
    Likes:
    4,428
    australia (brisbane)
    Theres an old post on immune abnormalities in xmrv positive patients and a study suggesting elevated cd8 lymphocytes and poor nk dysfunction are common in xmrv. At the moment funds stop me from getting tested for xmrv but others who have tested positive to xmrv, have they also had testing showing elevated cd8 lymphocytes and poor nk function???

    http://www.ncbi.nlm.nih.gov/pubmed/18801465 ,this study appears to have come from Italy, so xmrv is being found in other countries just not common knowledge.

    appreciate anyones advice or experience with this.

    cheers!!!
  2. Forebearance

    Forebearance Senior Member

    Messages:
    379
    Likes:
    104
    Great Plains, US
    I haven't had cd8 tested, but I am XMRV+ and tested low in NK cell function.
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,164
    Likes:
    4,428
    australia (brisbane)
    interesting. It would be interesting to know what other immune abnormalities xmrv+ have eg neutropenia etc

    cheers!!!
  4. Rrrr

    Rrrr Senior Member

    Messages:
    1,397
    Likes:
    263
    this is from an old post. i'm re-posting here, now:

    Treating cytokine up/down-regulation
    ______

    WPI & NCI Paper

    "Type 1 IFN Pathyway Response to Viral Infection in Chronic Fatigue Syndrome"

    Mikovits,J. Hagen,K. Peterson,D. Stephens,R. Lombardi,V.
    Whittemore Peterson Institute, Reno, NV, USA. Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, MD, USA.

    118 CFS patients
    138 Controls

    Cytokines/Chemokines:

    CFS:

    IL-8: 1045
    MIP-1a: 763
    MIP-1b: 1985
    IL-6: 336
    TNF-a: 148
    IL-1b: 500
    IP-10: 98
    IFN-a: 35
    IL-13: 28
    IL-7 160

    Controls:

    IL-8: 13
    MIP-1a: 91
    MIP-1b: 164
    IL-6: 29
    TNF-a: 13
    IL-1b: 56
    IP-10: 32
    IFN-a: 60
    IL-13: 86
    IL-7: 60

    Guide to Chemokines/Cytokines:

    IL-8: RNase L & CMV activated
    MIP-1a: Elevated in neurodegenerative disease
    MIP-1b: Elevated in neurodegenerative disease
    IL-6: Stimulates chronic inflammation
    TNF-a: Stimulates chronic inflammation
    IL-1b: Stimulates chronic inflammation
    IP-10: Interferon response protein
    IFN-a:Stimulates macrophages and NK cells to elicit an anti viral response
    IL-13: Inhibits inflammatory cytokine production
    IL-7: Stimulates proliferation of B & T lymphocytes & NK cells

    Summary and conclusions:

    Cytokine and Chemokine profiling in combination with machine logic algorythms reveals an inflammatory signature consistent with an over-expression of herpes virus and is useful for diagnosis for CFS
    ________

    more info on cytokine and chemokines

    http://www.forums.aboutmecfs.org/sho...l=1#post124292

    http://www.forums.aboutmecfs.org/sho...915#post127915 (posts #401 and those after it)

See more popular forum discussions.

Share This Page