I have had OI issues for years but in the last year or so these have become a real problem. I am not taking any meds for this just following the practical advice re fluids etc. Coincidentally, the menopause is starting. I'm not taking meds for this either as although I have hot flushes, these are typical of the flushes I've been having since I first became ill 20 years ago. So....I'm wondering if the worsening POTS is due to hormones and perhaps trying HRT might ease the POTS issue? Or should I try to address the POTS issues directly? What do you think?