I have mild POTS, anxiety, and pretty much most of the cognitive and sensory issues people with CFS have, but I don't have CFS and don't get PEM. Bottom line, have no idea what I have. It started 20 yrs ago after an infection. But what I do know is alcohol gives me a boost. Especially if I start drinking slow and give my body enough time to adjust to the vasodilation (at which point veins in my arms and legs get so gorged with blood they hurt from the pressure while my blood pressure is only 90/60). Once that part is gradually adjusted for, I get more mental energy, amazing mood enhancement, and pretty much feel more human and normal than I've felt all day. None of the supplements and meds I've tried can do this (I have yet to try any other GABA enhancers, don't see the point if I have alcohol, and benzos are likely worse for you than alcohol) What does this mean? Is it the vasodilation? Reduced anxiety? Raised cortisol? Action on GABA? NMDA antagonism? All I know if it's the most effective tool I have (including the useless Zoloft I take every morning) to make me feel human.