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NY Times: Same Genetic Basis Found in 5 Types of Mental Disorders

Discussion in 'Other Health News and Research' started by MishMash, Feb 28, 2013.

  1. MishMash

    MishMash *****

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    Hugely important. Think it isn't related to CFS or FM? Think again. Depression is highly related to CFS. A great percentage of people with our illness have a genetic susceptibility.

     
    SaraM, BEG, Waverunner and 3 others like this.
  2. beaverfury

    beaverfury beaverfury

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    Interesting. Does 23andMe test for these SNPs? CACNA1 (?)

    Anyone tried Nimodipine ?
     
  3. Valentijn

    Valentijn Activity Level: 3

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    I have yet to see a study using appropriate questionnaires or other methods to determine any mood disorders in ME patients. On the other hand, I have read a ton of studies using questionnaires where physical or cognitive limitations can account for giving answers which are interpreted to mean mood disorder is present.

    If you know of any studies that back up your statement regarding depression in ME or a genetic susceptibility, rather than equating disability with depression, please share it so that I can be enlightened.
     
    ukxmrv likes this.
  4. SilverbladeTE

    SilverbladeTE Senior Member

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    Somewhere near Glasgow, Scotland
    and if these illnesses are autoimmune, WHAT PROVOKES THE AUTOIMMUNE RESPONSE, EH?
    let me see...
    adjunctivants ("Meat's back on the menu, boys!" or rather Andrew Wakefield...)
    heavy metals (UK governemnt let chilren be soaked in lead fumes until 2000 even though they knew the danger)
    organophosphates (again UK government lies to protect the companies many of them end up working for!)
    excess disease spread caused by air travel and confining people especially kids in huge numbers in poorly ventilated buildings

    mmmm and we wonder why we have problems?
     
    golden likes this.
  5. natasa778

    natasa778 Senior Member

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    just copying my post from another thread


    That case study was nimodipine I believe. The docs figured post viral ME was there 'cos of viruses messing up ion channel function ... which is the crux of my theory :) certain polymorphisms, both in ca channel themselves AND in nearby G-protein linked (esp chemokine!!!) receptors will push you over the limit following environmenal / external events
     
    MishMash likes this.
  6. beaverfury

    beaverfury beaverfury

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    Hi Natasa,

    What class of drugs antagonize chemokine receptors? I'm not going to pop one, don't worry. Just trying to fill out
    my me/cfs knowledge base.

    http://autismcalciumchannelopathy.com/
    http://autismcalciumchannelopathy.com/Conclusion.html
    These links are good. Once again the theories fit the pathologies of me/cfs, as so many other theories do.
    I just wish they could jump ahead and fit an effective treatment to me/cfs.

    Regards Nimodipine ,I havent been able to find any trials. Anecdotally it sounds promising, but not world beating.
    http://livingwithchronicfatiguesyndrome.wordpress.com/2012/11/26/nimodipine-for-me/

    Dr. Mason Brown has seen many of his ME/CFS patients improve with Nimodipine usage. He writes, “Nimodipine helps twenty per cent (of ME/CFS patients) very quickly, another twenty per cent over six months, and all others to varying degrees over a period of time.” He improved his own health to 95% with Nimodipine usage as a treatment for his ME/CFS. He states “The work of nimodipine is at least fourfold: to release the backlog of neurotoxins and waste products from the brain, to open up the brain circulation, to allow in oxygen and nutrients to enter and to help cognitions, pineal, hypothalamic, and pituitary function.”
    Dr. J. Goldstein, now retired, specialized in the treatment of ME patients in California. He used Nimodipine as a primary treatment for M.E. and has called it “one of the most useful treatments for ME/CFS and Fibromyalgia.” He also writes, “About 40% of CFS/FM patients taking nimodipine experience relaxation, increased energy, a decrease in tender point sensitivity, improved exercise tolerance, and enhanced mental clarity…. Nimodipine has been shown to release dopamine, serotonin, and acetylcholine…. Tolerance does not develop to the vasodiliatory effects of nimodipine, but sometimes does to its amelioration of CFS/FM symptoms.” He recommends taking 30mg to 60mg 3 times a day.
     
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  7. natasa778

    natasa778 Senior Member

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    LOL
    there are none, unfortunately. At least there wasn't one couple of years ago when I last looked, apart from ONE super promising brand new drug entering phase II trials when I last looked. Japanese. I have tried searching since but lost the link and drug's name and now can't find it so no idea what is happening to it ... it was a specific CCR antagonist....
     
  8. PhoenixDown

    PhoenixDown Senior Member

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    Depression is really a big misnomer and the word shouldn't be used in the context of defining health conditions, it guarantees confusion and therefore worse treatment of patients by doctors & society as a whole. It's been a waste-basket diagnosis since it's inception, this is NOT to say that people with this diagnosis have nothing wrong with them.
     
  9. Jenny

    Jenny Senior Member

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    Yes, I had a brain haemorrhage a few years ago and was put on it for a few months. My ME got quite a lot better but that could just have been chance (it was summer and I'm usually better then). I've tried lower doses since, which didn't help. I might try to persuade a doctor to give me the higher dose again when I've finished the various treatments I'm doing at the moment.

    There are lots of threads on this drug.
     
  10. MishMash

    MishMash *****

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    Not true. They are talking about "Major Depressive Disorder" which shows up very profoundly in brain scans and tests. You might be thinking of minor depression, situational melancholia, "the blues." MDD has organic roots and can be crippling.

    Nobody has agreed on what the exact parameters of CFS are; something I think most people can agree on. (Does it include PEM? Or doesn't it?) But in my personal experience, many folks with CFS have parents, relatives with MDD, bipolar, ADD, etc.
     
    SaraM likes this.
  11. Hip

    Hip Senior Member

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    Both the CDC definition and the Canadian Consensus definition of CFS include PEM.
     
  12. natasa778

    natasa778 Senior Member

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    just found this, from 2011




    calcium antagonists (nifedipine I believe) were trialled in phase two for HIV - neuroAIDS, results looked promising but don't think it ever went to phase 3 ...
     
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  13. PhoenixDown

    PhoenixDown Senior Member

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    That doesn't change the fact that it is commonly used as a waste-basket diagnosis. Also remember those scans are NOT done on the millions diagnosed with major depressive disorder. The fact that it can be crippling doesn't stop it from being a waste basket diagnosis handed out when doctors can't be bothered to investigate or have prejudices against the patient.


    The CDC & CCC definitions do not exclude those without PEM, only the ICC criteria does this.
     
  14. MishMash

    MishMash *****

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    Natasha,
    Your theory sounds good (or the theory you quoted)!
    Given what was strongly represented in the results of this huge study, your explanation is now the front-runner, coming down the finish line. But are there several other polymorphisms that overlap, changing our disease process?
     
  15. natasa778

    natasa778 Senior Member

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    LOL. Yes absolutely (re your question) ... interferon polymorphisms also seem involved, at least in autism. Also serotonin ... I also suspect HERV polymophisms will play a big role, including in ME (already indicated in MS)!
     
  16. August59

    August59 Daughters High School Graduation

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    I saw his interview on TV and he seemed very excited as well for his partners. A lot of what he said was above my head, but I definitely picked up on the calcium-channel blockers. One thing that may be real good to come out of it is that it will possibly supply a diagnostic marker!??!?1

    But, he did say that there were family lines that had all of the morphisms(?) and none of them had any of the 5 diseases.
     
  17. natasa778

    natasa778 Senior Member

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    Yes of course, genetic polymorphisms are not causative factors, but point to vulnerability ...
     

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