After opinions on these meds in adrenal fatigue. As i understand it NRI- noradrenaline reuptake inhibitors dont stimulate the adrenals to produce nor adren but make the nor adren we do produce last longer. This sounds like an advantage in treating adrenal fatigue but a google of the internet seems to say otherwise. I can understand how it may increase energy and encourage you to push yourself but also as long as u dont go running marathons everyday, this extra energy is better then being wrapped in cotton wool all the time, always keeping in mind to rest and recover from activities. Im bringing this subject up as i have had good response from reboxetine/edronax which is a NRI. Im taking a very low dose compared to the doses used in depression which is 4 mg twice a day, Im only taking 1mg in the morning and because it has a short half life, it isnt impacting my crappy sleep.I have only been on it 4 days so far. Before using edronax i was feeling down and lethargic and getting very unmotivated, brain fogged etc etc. Now i have used edronax a few times before but have stopped it quickly due to side effects like insomnia, perfuse sweating, but it did give me good energy. I think the difference is that this time my viral load is down from antivirals, which was also confusing as i wasnt really feeling any better although i felt different, less viral which is why i was persuing adrenal fatigue treatments. Fingers crossed that it keeps working for me, but i think that because this illness is neurological as well as immunological theres 2 things we need to treat. Im not sure if its poor adrenals or just that brain cells that have been switched off for so long need a jump start to start working again, im leaning towards the brain cells being switched off as adrenal fatigue treatments havent helped fully. So from day 1 on edronax i have been feeling better, dare i say it, almost normal??? yesterday i had the urge to clean the garden shed out which has been on my to do list for quite some time. This garden shed is actually my gym so i was moving some heavy stuff around to clean it up and was at it for a few hours too. SOmething like this 2 weeks ago i would had to have set a bomb off to get me to even start it and then i would have collapsed while doing it and crashed badly afterwards. I have woken up this morning alittle stiff but feeling good, clear headed just all good, but today i am taking it easy as i really dont want to crash, so i am being weiry of overdoing it and i really hope it continues to work. Side effects that i had in the past from using edronax i havent had this time so far. Go's to show that we should retry old treatments we have stopped every so often. antidepressants is a bad name for these meds just like cfs is for our illness, they should be called neurological meds as they dont just help with depression but function of our nervous sytem which is so out of whack. Dosing has to be careful with cfs as our neurology is very different to someone who just has depression and using depression dosages. So far from my experience, i think they seem to work better when the immune side of things are more under control. I have 4 days of work in a row coming up, mmm lets see how i go as this will test the waters. I will keep u posted. cheers!!!