How about this as an initial attempt at reworking item no. 2? (comments and feedback please): 2aii. A new definition should be created, that will involve a panel of physicians expert in the field of CFS/ME, and who have an understanding of the physiological abnormalities in CFS/ME patients. The new definition should be based on independently replicated published scientific papers in relation to the physical symptoms, and physiological abnormalities in CFS/ME patients. The new definition will exclude patients who test positive for all other diseases, as per item no. 1., using the differential diagnosis list and testing requirements that will have been created when article 1a has been accomplished. A review of the medical literature must be done, to compile a list of all physical anomalies that have been found in CFS and ME patients, such as SPECT, PET, MRI scans, NK cells, RNase L, VO2 max, POTs, NMH etc, etc. Tests for the most significant of these anomalies (as decided by the panel of experts) will be performed in a replicated manner on a representative selection of selected cohorts of patients in order to create the diagnostic definition. From this information a new definition will be written, and further definitions, if it found to be more than one different illnesses.