Since a lot of people have problems with it, I thought this small note was interesting: http://en.wikipedia.org/wiki/Carbamoyl_phosphate_synthetase "Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis of carbamoyl phosphate from glutamine (EC 22.214.171.124) or ammonia (EC 126.96.36.199) and bicarbonate... It represents the first committed step in ... the urea cycle." Type 1 is found in the mitochondria. So, ammonia problems could be improved by improving ATP synthesis! How 'bout that?