Basic protocol was going OK until I added glutathione and grass-fed whey to the mix. Suddenly the real live actual *energy* I've been feeling was gone and I didn't know why.... Until I stumbled on Fredd's comments about exogenous glutathione/precursors. Removed both, bumped up the B and the energy more or less returned. THANK YOU FREDD! I've spent weeks reading, trying to understand how this all works and clearly I'm still confused. I don't want another setback so I'm just going to ask for your input/guidance. Please. Any suggestions on what to do/not do would be much appreciated. Main issues: life-stopping fatigue (mental/physical), bizarre weight gain do not have pain do not have GI issues I've made all the usual "lifestyle" changes have a history of TBI (1999, 2001) This has been going on for almost 2 years. Has happened twice before after prolonged periods of extreme stress, but not to this extent. Been diagnosed with "maybe lupus", "could be CFS", adrenal fatigue (cortisol panel was fine). Drs basically have no idea. 23+me results: VDR taq +/+ COMT v158m +/+ COMT h63h +/+ MTRR a66g +/+ MTHFR a128c +/- BHMT 2, 4, 8 +/+ CBS c699t +/- I know COMTs are supposed to overmethylate, but think my VDR status complicates this? Not 100% clear. I have never experienced what other people describe as overmethylation and have tried different combos of methyl donors at once. I do get activated from mB12 but in a way that just feels... alive. Drs have run every test know to man, most are normal. Exceptions: B12 - high 1485 nr (211-946) Have always tested high, even when I was vegetarian for 10+ years. Was bad about supplementing; guessing it came from food additives. I now eat meat, no longer eat processed food and levels have come down over the years but still not normal. DHEA - low 60 nr (64-357) Has been this low for a year, apparently not great for a 40 y/o female. Has not responded at all to low dose DHEA/pregnenolone supplementation, per Dr. A1C - high 5.7% This one puzzles me. Have tracked glucose with home meter, before/after meals. It's always in the 90-120 zone (high as 120 is infrequent). Fasting insulin was on very low end of normal. MCV - 97 highest level = 107 lowest level = 94 (saw Fredd mention this, not sure where it fits) Vit D - I have S.A.D and understand that D levels can effect severity. I'm constantly outdoors in the sun (Nor California) and supplement D in high doses (10,000 - 20,000 IU/ day, depending on season) but have a hard time getting levels to reach/stay above 50. Thinking this relates to VDR taq +/+?? Triglycerides low side (~20) Apologies for the epic-ness of this post. Did my best to be thorough yet concise :| Thank you in advance!