Basic protocol was going OK until I added glutathione and grass-fed whey to the mix. Suddenly the real live actual *energy* I've been feeling was gone and I didn't know why.... Until I stumbled on Fredd's comments about exogenous glutathione/precursors. Removed both, bumped up the B and the energy more or less returned.
THANK YOU FREDD!
I've spent weeks reading, trying to understand how this all works and clearly I'm still confused. I don't want another setback so I'm just going to ask for your input/guidance. Please. Any suggestions on what to do/not do would be much appreciated.
Main issues: life-stopping fatigue (mental/physical), bizarre weight gain
23+me results:
VDR taq +/+
COMT v158m +/+
COMT h63h +/+
MTRR a66g +/+
MTHFR a128c +/-
BHMT 2, 4, 8 +/+
CBS c699t +/-
I know COMTs are supposed to overmethylate, but think my VDR status complicates this? Not 100% clear. I have never experienced what other people describe as overmethylation and have tried different combos of methyl donors at once. I do get activated from mB12 but in a way that just feels... alive.
Drs have run every test know to man, most are normal. Exceptions:
B12 - high 1485 nr (211-946)
Have always tested high, even when I was vegetarian for 10+ years. Was bad about supplementing; guessing it came from food additives. I now eat meat, no longer eat processed food and levels have come down over the years but still not normal.
DHEA - low 60 nr (64-357)
Has been this low for a year, apparently not great for a 40 y/o female. Has not responded at all to low dose DHEA/pregnenolone supplementation, per Dr.
A1C - high 5.7%
This one puzzles me. Have tracked glucose with home meter, before/after meals. It's always in the 90-120 zone (high as 120 is infrequent). Fasting insulin was on very low end of normal.
MCV - 97
highest level = 107
lowest level = 94
(saw Fredd mention this, not sure where it fits)
Vit D - I have S.A.D and understand that D levels can effect severity. I'm constantly outdoors in the sun (Nor California) and supplement D in high doses (10,000 - 20,000 IU/ day, depending on season) but have a hard time getting levels to reach/stay above 50. Thinking this relates to VDR taq +/+??
Triglycerides low side (~20)
Apologies for the epic-ness of this post. Did my best to be thorough yet concise :|
Thank you in advance!
THANK YOU FREDD!
I've spent weeks reading, trying to understand how this all works and clearly I'm still confused. I don't want another setback so I'm just going to ask for your input/guidance. Please. Any suggestions on what to do/not do would be much appreciated.
Main issues: life-stopping fatigue (mental/physical), bizarre weight gain
- do not have pain
- do not have GI issues
- I've made all the usual "lifestyle" changes
- have a history of TBI (1999, 2001)
23+me results:
VDR taq +/+
COMT v158m +/+
COMT h63h +/+
MTRR a66g +/+
MTHFR a128c +/-
BHMT 2, 4, 8 +/+
CBS c699t +/-
I know COMTs are supposed to overmethylate, but think my VDR status complicates this? Not 100% clear. I have never experienced what other people describe as overmethylation and have tried different combos of methyl donors at once. I do get activated from mB12 but in a way that just feels... alive.
Drs have run every test know to man, most are normal. Exceptions:
B12 - high 1485 nr (211-946)
Have always tested high, even when I was vegetarian for 10+ years. Was bad about supplementing; guessing it came from food additives. I now eat meat, no longer eat processed food and levels have come down over the years but still not normal.
DHEA - low 60 nr (64-357)
Has been this low for a year, apparently not great for a 40 y/o female. Has not responded at all to low dose DHEA/pregnenolone supplementation, per Dr.
A1C - high 5.7%
This one puzzles me. Have tracked glucose with home meter, before/after meals. It's always in the 90-120 zone (high as 120 is infrequent). Fasting insulin was on very low end of normal.
MCV - 97
highest level = 107
lowest level = 94
(saw Fredd mention this, not sure where it fits)
Vit D - I have S.A.D and understand that D levels can effect severity. I'm constantly outdoors in the sun (Nor California) and supplement D in high doses (10,000 - 20,000 IU/ day, depending on season) but have a hard time getting levels to reach/stay above 50. Thinking this relates to VDR taq +/+??
Triglycerides low side (~20)
Apologies for the epic-ness of this post. Did my best to be thorough yet concise :|
Thank you in advance!