Hi all, I posted in the general treatment forum but my post was quite long and scattered. I'll try to sum it up here! Here's my original thread if interested. I'm 29 years old, mostly housebound at the moment, not able to work but am a full-time single mom (need lots of help though). Have lots of muscle pain, nerve pain, joint pain, BRAIN FOG (HATE HATE THIS!), muscle cramps, fatigue, post exertional malaise, depression, anxiety, irritability, no zest for life, vertigo, sinus problems, daily headaches, the list goes on!! I'm very angry that I'm like this. I'm very much in mourning for the life I should be having. A doctor at the Cleveland Clinic tested me for MTHFR last August, and it turns out I have one copy of the MTHFR C677T mutation. I've been told that this isn't that severe, but she did put me on Metanx and I noticed an improvement pretty much right away. However, I'm a little over a month in (only started taking consistently in January) and am starting to get old symptoms back. I realize I need to work on a lot of things to get any kind of better, but I'm so overwhelmed and not sure where to start. Should I be focusing on methylation at all? I have lots of lab work...most things are normal except for low levels of inflammation over the years. I can post lab results if needed. Any advice at all would be so helpful. I'm feeling very down, as if there's no light at the end of the tunnel. Especially after reading that the average age of death for someone with CFS is 55!! Ugh! I would give anything for more of a life than this...to be a good mom and be there for my son. Anyway, off to sulk now (PMS doesn't help!!). Thank you in advance.