Racetams- piracetam, oxiracetam etc etc said to be cognitive enhancers that modulate neurotransmitters glutamate and acetylcholine. said to promote inter-hemispherical communication via corpus collosum. Commonly used by students for studying or anyone trying to improve memeory and memory recall, also used for dementia and alzheimers. Choline three main physiological purposes: structural integrity and signalling roles for cell membranes, cholinergic neurotransmission (acetylcholine synthesis), and a major source for methyl groups via its metabolite, trimethylglycine (betaine) which participates in the S-adenosylmethionine (SAMe) synthesis pathways. Centrophenoxine aka meclofenoxate can be used as a source of choline/replacement of, cognitive enhancer, improves memory and mild stimulating properties. Also increases cellular membrane phospholipids. Stimulated glucose uptake by the brain. Lipofuscin is a build up of potassium in the brain, heart lung and skin cells, centro is said to help remove this build up.Commonly used as a nootropic/smart drug, dementia, alzheimers. Alpha GPC is a metabolite of choline that is said to be absorbed better and cross the blood brain barrier better then choline. supports brain function by directly increasing the synthesis and secretion of acetyl choline and protects neurons. Commonly used as a nootropic smart supplement and used with racetams to support their function. Choline CDP similar benefits to other choline type supps, said to be able to cross the blood brain barrier well. Huperzine A is an acetylcholinesterase inhibititor which slows the break. down of acetylcholine. It is also a NMDA receptor antagonist which can protect the brain from glutamate induced damage. Speculation that NMDA antagonists can help reduce benzo tolerance. So its another nootropic/smart supplement. Vinpocetine Vinpocetine is reported to have cerebral blood-flow enhancing and neuroprotective effects, and is used as a drug in Eastern Europe for the treatment of cerebrovascula disorders and age-related memory impairment. Vinpocetine is widely marketed as a supplement for vasodilation and as a nootropic for the improvement of memory. In other words, Vinpocetine may help support brain functions such as concentration and memory by activating cerebral metabolism. Vinpocetine has been identified as a potent anti-inflammatory agent that might have a potential role in the treatment of parkinsons disease and Alzeimhers disease. Sulbutiamine derivative of thiamine/vit b1 and more easily crosses the blood brain barrier then b1 itself. It is used to treat asthenia, chronic fatigue, improve ememory. Phenibut derivative of a naturally occurring inhibatory neurotransmitter gaba and appears to affect gaba b receptors. It is also classed as a nootropic and its tranquilizing effects are said to help reduce stress and anxiety, improve impaired sleep, reduce neuralgia's and has muscle relaxing qualities. Tolerance is said to occurr rapidly so use should be limited to once or twice a week. Picamilon combines niacin and gaba and is said to help gaba cross the blood brain barrier more effectively then gaba alone. Possibly activates gaba receptors producing calming properties. Also said to have vasodilation affects from niacin. Used for rehabilitation of stroke victims, asthenia, depression, alcohol detox, migraines and neuro infections. Its calming affect would be useful to improve sleep quality as well. The above are supplements and a quick google will help one find a source of these supplements. I think these types of supps can help us treat the neurological aspects of cfs/me. cheers!!!