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(Not ME/CFS-specific) "Tricyclic antidepressants 'raise cardiovascular risk'"

Discussion in 'Other Health News and Research' started by Dolphin, Dec 2, 2010.

  1. Dolphin

    Dolphin Senior Member

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    [Quite a lot of patients with ME/CFS take these drugs. On the face of it, this is a bit worrying but patients on tricyclics may be quite ill. I haven't seen the full paper to see what they controlled for.]

    http://www.pulsetoday.co.uk/story.asp?storycode=4127924

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    CLINICAL RESEARCH:
    Mark Hamer, G. David Batty, Adrie Seldenrijk, and Mika Kivimaki Antidepressant medication use and future risk of cardiovascular disease: the Scottish Health Survey Eur Heart J first published online November 30, 2010
    doi:10.1093/eurheartj/ehq438
  2. Esther12

    Esther12 Senior Member

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    They're commonly used for chronic pain and migraines now. I wonder if these conditions would be related with cardiovascular problems regardless of treatment.
  3. Dolphin

    Dolphin Senior Member

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    Yes. They help so many of my symptoms that I'm reluctant to stop. Of course, if the core illness was treated, I might have fewer symptoms and they'd be less severe and it'd be easier to give them up.
  4. We are supposed to be taking them in tiny doses - ie 10mg while a proper dose for depression is more like 45 - 50mg. Certainly the 10 mg gives me a great sleep - and is generally great for me. Amytriptyline saved my life as sleeping probs were terrible - I went up to 30mg at the very worst time but needed to only for a couple of weeks then reduced to 20 and then 10 again. If the research was looking at the does for depression then our lower doses are no doubt a whole lot safer.

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