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Norwegian rituximab study to start 2014

Discussion in 'General ME/CFS News' started by Ninan, Dec 5, 2013.

  1. Firestormm

    Firestormm

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    Cornwall England
    Yeah I must admit - and without time to look again at the published paper - but I thought it was Fukuda and CCC first time. Might be wrong, but I didn't think it was only Fukuda because that would have raised more concerns among the patients...

    @Bob can you remember off the top of your head? Thanks :)
     
  2. Ninan

    Ninan Senior Member

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    It was only Fukada. But later they found that almost all patients (except maybe two, not sure) fitted CCC.

    Now since Rituximab probably doesn't have much effect on depression I guess using CCC will increase the number of responding patients rather than decrease it. They have seen better results in later studies. This could be due to using better criteria.
     
  3. Ninan

    Ninan Senior Member

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    "The inclusion criteria were: a diagnosis of CFS by a neurologist, according to the Fukuda 1994 criteria [5], age 18–65 years, and written informed consent. Exclusion criteria were: fatigue not fulfilling CFS criteria, previous malignant disease (except basal cell carcinoma and cervical dysplasia), previous long-term immunosuppressive treatment, previous Rituximab treatment, endogenous depression, lack of ability to adhere to protocol, or evidence of on-going infection."

    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026358
     
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  4. Firestormm

    Firestormm

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    Thanks @Ninan I am flicking back and forth between editing an article - and my brain cell went on strike :)
     
  5. Ninan

    Ninan Senior Member

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    Yeah, I know it sucks to have only one. ;)
     
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  6. user9876

    user9876 Senior Member

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    I thought that they had a placebo response from someone fulfilling the Fukada definition but not the CCC one.
     
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  7. Ninan

    Ninan Senior Member

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    That's possible. I don't remember.
     
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  8. Valentijn

    Valentijn Senior Member

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    That's what I recall as well ... that the "cured" placebo patient was not CCC.
     
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  9. Ninan

    Ninan Senior Member

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    Maybe they found the one with the "bodily distress syndrome". Escaped from Denmark. :D
     
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  10. aimossy

    aimossy Senior Member

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    Its been a while I am hoping their last paper will be published within a few months from now.

    Edit. actually just realised it wasn't long since I looked here.....completely lost with time frames at the moment.:)
     

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