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Norwegian rituximab study NOT started

Discussion in 'Rituximab: News and Research' started by Roy S, Oct 13, 2012.

  1. rosie26

    rosie26 Senior Member

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    I shudder every time I see the word 'prednisone'. I found it utterly intolerable after just taking one tablet. Hope immunosuppressants don't give me the same problem if ME is autoimmune.
    aimossy likes this.
  2. aimossy

    aimossy Senior Member

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    it is a secondary mechanism by depleting auto antibodies is the principle behind autoimmune mostly.calms down what is overactive. that is something they will be trying to find out markers wise.
    if in phase 3 trials that percentage of success is the same as phase 2 its pretty huge because phase 3 is where results fall down.
    Even in autoimmune diseases not everyone responds to the same drugs it would be a massive proof of principle and proof of disease if phase 3 cracks it.

    I thought Dr Kolgelnik was doing studies on ritux in usa along with virus modulators and something else is that thru OMI-Merit.?
    I would be concerned if people are just going and getting ritux and its not in a controlled study?
    If this does pan out another immunosepressant might work for people that didn't respond to ritux but studies need to be done properly?
    I don't really know whats going on with the Dr Kolgelnik stuff.

    I don't think that all autoimmune things are prescribed prednisone it depends.

    It was heartening to see someone write more has come to light sooo looking forward to hearing about that.:)
  3. justy

    justy Senior Member

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    This seems such an important post I wonder if it could have its own thread - I only stumbled across it in here and im sure many others would like to hear this news, especially the statement about rituximab treatments :)

    Mods can this post be the basis for a new thread?
    aimossy likes this.
  4. alex3619

    alex3619 Senior Member

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    Rituximab could change everything, at least for those patients who respond to it. Sadly that is not everyone.

    It might also change the politics. How can a B cell destroying drug cause remission in a psychosomatic illness? Answer: the placebo effect is not powerful enough to do this, so the psychogenic hypothesis is obsolete for at least a large subset of patients. My gosh, they were wrong again! ;) Add psychogenic CFS to the absurdly long long long long long long long list of failures.

    It is as fair to say our immune systems are overactive as underactive. There are imbalances, with some parts given a big oomph, and other parts suppressed. NK cell function is suppressed. It looks like T cells are working too hard. We seem to have a very high turnover of B cells, though this needs a lot more research to be sure. We might have clonal expansion of gamma delta T cells. Some cytokines seem abnormally low or high.

    Most immunosuppressants target most of the immune system. They are not specific enough, but might be helpful in really low doses.
  5. Sing

    Sing Senior Member

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    Well, I appreciate the specific research now, seeing what happens by targeting just the B cells with rituximab. Because isn't it possible that the insurance cos and govt could try to have us take a broad spectrum immunosuppressant drug such as prednisone is, I think, with all of its harmful side effects, just because it is a lot cheaper?
  6. rosie26

    rosie26 Senior Member

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    I agree @alex3619 my illness feels part overactive and part underactive.
    I can have both reactions with my heart symptoms "sometimes my heart feels suppressed and hardly beating and at other times it is beating like I have just run a marathon. Just one example.
    Overstressed and aimossy like this.
  7. Snow Leopard

    Snow Leopard Senior Member

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    That's why we'd describe it as dysfunctional, rather than overactive or underactive.
    Overstressed and heapsreal like this.
  8. aimossy

    aimossy Senior Member

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    well I have been hoping we might be in luck for this to be published as an xmas present .....
    I have been good....... well this week I have been.:cautious::)
    rosie26, ggingues and MeSci like this.

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