Hi, I've been using noots for 4 years of my nearly 6 years post ME diagnosis. I have listed noots/supplements that have had no detrimental effects, only positive results. If you take a look at the brilliant work of the Osaka team PET scanning ME patients to scientifically prove neuroinflammation in ME patients in the link, you will appreciate why noots may be part of the solution to dealing with cognitive symptoms in ME patients. I am working on a correlation between damaged brain areas and ME symptoms based on the Japanese findings at the mo and will post the results when I have them. Link to PET scan study- http://jnm.snmjournals.org/content/55/6/945.long#ref-24 List of noots/supplements I have used (there are others but I don't feel it would be beneficial to list the ones in 3rd stage trials). Please note, what works for me may not work for you, also I highly recommend researching neurogenesis, brain plasticity and synaptogenesis prior to cautiously dipping your toes in the water. One at a time, low dose and monitor for a week or so to ensure compatibility/effectiveness. Lion's mane mushroom Bacopa monnieri Huperzine A Ashwagandha Strong coffee! GABA 5-HTP Alpha GPC or choline/choline bitartrate L-theanine Vinpocetine Resveratrol Noopept (GVS-111) I urge you to read and understand how the above functions prior to trying. Be cautious!