1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Lessons from ME/CFS: Finding Meaning in the Suffering
If you're aware of my previous articles here at Phoenix Rising then it's pretty clear that I don't generally spend my time musing upon the philosophy of the disease. I find it better to spend my time reading research and trying my best to break it down to its core elements and write...
Discuss the article on the Forums.

No MTHFR should I switch back to folic acid from metafolin?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Al Klein, Aug 6, 2013.

  1. I started taking metafolin after reading about MTHFR but now it turns out I dont have it, and possibly need to cut down on methyl groups (I currently take L-methylfolate 800mc and Jarrows Methylcobalamin 5000 per day, plus I get hydroxycobalamin shot every 8 weeks - I have pernicous anemia), so would I be better to go back to a traditonal Folic acid?

    These are my relevant SNP's from gentic genie:


    COMT V158M rs4680 AA +/+
    COMT H62H rs4633 TT +/+
    VDR Bsm rs1544410 CC -/-
    VDR Taq rs731236 AA +/+
    MAO-A R297R rs6323 TT +/+
    MTRR A66G rs1801394 GG +/+
    MTRR A664A rs1802059 AG +/-
    BHMT-02 rs567754 CT +/-
    BHMT-04 rs617219 AC +/-
    AHCY-01 rs819147 CT +/-
    AHCY-02 rs819134 AG +/-
    AHCY-19 rs819171 CT +/-
    CBS C699T rs234706 AA +/+
  2. Critterina

    Critterina Senior Member

    Messages:
    735
    Likes:
    322
    Arizona, USA
    Al,
    I'm a newbie here, so please consider the advice of the Senior Members with a lot more weight than mine. And please read http://forums.phoenixrising.me/index.php?threads/the-stages-of-methylation-and-healing.21725/. It seems there's little to indicate that extra regular folic acid is a good thing.

    Because you, like me, have MTRR (+/+), it means you don't make methylcobalamin (MB12) as efficiently as someone without it. I would say if you're doing well, that it's probably good that you take MB12, but there are a lot of other considerations.

    First, you're COMT (+/+) so you risk methyl group overload from extra methyl groups. Know the symptoms of over-methylation and watch for them.
    Second, you're CBS (+/+) which sucks up all the homocysteine and draws down your methionine. I'm assuming you're MTR (-/-), so that may limit the reaction, but the MTR uses the methyl folate (MTHF) to replace the methionine that turns into homocysteine, all of which could be accelerated by the CBS. For me, (I have +/- for both MTR and CBS, and was taking my MTHF with Vitamin C, which apparently destroys it), I got into what's called First level methylation blockage. For safety, know the symptoms and watch for them if you decide to keep taking it.
  3. Thanks - I know I need to read more, but in the past week I have read so much my brain is fit to burst.

    It was only last night that I read about not taking MTHF with Vit C so tonight will be me first time keeping them separate - I must read about methyl overload!
    Thanks :)
  4. caledonia

    caledonia

    Messages:
    2,872
    Likes:
    1,459
    Cincinnati, OH, USA
    You probably don't need to supplement with folate at all, especially if you're eating your leafy greens. I would avoid "folic acid" no matter what mutations you may or may not have.

    For your COMT and VDR mutations, Yasko suggests hydroxy and adenosylcobalamin.

    You're already taking high doses of methyl supps and apparently tolerating them ok, so it sounds like your CBS is not expressed, so you don't need to worry about that.

    You might want to take some TMG for the BHMT mutations to keept the secondary pathway going. TMG is another methyl donor, so keep the dose low and/or titrate up slowly.

    In general, you might want to keep some niacin in the form of nicotinic acid on hand while you're experimenting with methyl supps. If you get into an overload situation, you can quickly quench it by taking 50-100mg every 4 hours. You might only need one dose, you might need several, depending on how far you went overboard.
  5. TMG?

    thanks
  6. Critterina

    Critterina Senior Member

    Messages:
    735
    Likes:
    322
    Arizona, USA
    TMG is trimethylglycine. It's found in lamb, quinoa, and beets, and other foods, and in supplements.
  7. If you look again I think youll find the "lamb" is actually a plant - lamb's quarters!
    http://en.wikipedia.org/wiki/Trimethylglycine

    Quinoa on the shopping list for tomorrow :)
  8. Bluebell

    Bluebell Senior Member

    Messages:
    392
    Likes:
    210
  9. Critterina

    Critterina Senior Member

    Messages:
    735
    Likes:
    322
    Arizona, USA
    Al,
    The lamb was in my frying pan; it's been eaten since then. I was writing from memory, not from something to look at. Last fall I was on an elimination diet and it seemed all I ate was quinoa and nuts for breakfast, salad (with beets) for lunch (no tomatoes, peppers or spinach - I reacted to them!), cooked beet greens, other greens or cooked vegetables and lamb patties for dinner. Oh, how boring!

    But I see you are correct, that lambsquarters are on the list at http://nutritiondata.self.com/foods-000145000000000000000-1w.html.

    Hmmm, when I had my blood work done after that period and then three months later, when my diet was more 'normal', my methionine had dropped, and I noticed that a lot of foods on the elimination diet had been high in TMG (a.k.a. betaine, sold as betaine anhydrous, not the digestive aid betain HCl) which regenerates Methionine. I thought it was quinoa, beets, and lamb. Maybe it was one of the substitute meats I used - bison, elk, or eventually turkey.

    Anyway, you are right. We have a lot to learn here, and being thorough like you are is going to serve you well.
    Al Klein likes this.

See more popular forum discussions.

Share This Page