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NK cell function & Signals From Gut Bacteria

Discussion in 'Other Health News and Research' started by kaffiend, Jul 2, 2012.

  1. kaffiend

    kaffiend Senior Member

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    California
    I have not read this paper yet, but the article looks fascinating. The researchers are finding the molecular link between gut bacteria, dendritic cells and NK cell function (in mice).

    Press release: http://www.sciencedaily.com/releases/2012/07/120702152940.htm

    Original Article: http://www.cell.com/immunity/retrieve/pii/S1074761312002439

    Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

    Abstract
    Mononuclear phagocytes are an important component of an innate immune system perceived as a system ready to react upon encounter of pathogens. Here, we show that in response to microbial stimulation, mononuclear phagocytes residing in nonmucosal lymphoid organs of germ-free mice failed to induce expression of a set of inflammatory response genes, including those encoding the various type I interferons (IFN-I). Consequently, NK cell priming and antiviral immunity were severely compromised. Whereas pattern recognition receptor signaling and nuclear translocation of the transcription factors NF-κB and IRF3 were normal in mononuclear phagocytes of germ-free mice, binding to their respective cytokine promoters was impaired, which correlated with the absence of activating histone marks. Our data reveal a previously unrecognized role for postnatally colonizing microbiota in the introduction of chromatin level changes in the mononuclear phagocyte system, thereby poising expression of central inflammatory genes to initiate a powerful systemic immune response during viral infection.
     
    PWCalvin likes this.
  2. globalpilot

    globalpilot Senior Member

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    Ontario
    Nlice find! Now they were lookign at germ free mice. I wonder how this applies to us who are not germ free but may have lower levels of the commensal bacteria and higher levels of yeast and the harmful bacteria.
     

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