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Nk cell defiencies and herpes viruses

Discussion in 'Other Health News and Research' started by heapsreal, Dec 23, 2011.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    There are a surprisingly large number of human natural killer (NK) cell deficiency states that provide insight into the role of NK cells in defense against human infectious disease. Many disorders associated with NK cell defects are caused by single gene mutations and, thus, give additional understanding concerning the function of specific molecules in NK cell development and activities. A resounding theme of NK cell deficiencies is susceptibility to herpesviruses, suggesting that unexplained severe herpesviral infection should raise the possibility of an NK cell deficit.

    http://www.ncbi.nlm.nih.gov/pubmed/12505527
     
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  2. Enid

    Enid Senior Member

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    No scientist heaps - this in the light of findings/suspects so far certainly makes sense to me.
     
  3. allyb

    allyb Senior Member

    I am no scientist either, in my ignorance I often wonder 'chicken and egg' would you catch a virile strain of the herpes virus because you already had single gene mutations in your NK cells or would the virile strain of herpes that you had caught cause a single gene mutations in your NK cells?

    As I am relatively new to PR I don't know if this has been posted and discussed before (should it be on a thread of its own?) My apologies if it has but I would love your opinion and that of others.
    kind regards
    allyb

    link

    http://www.wehi.edu.au/site/latest_...ew_targets_for_eliminating_chronic_infections

     
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I did come accross a few links to a dysfunctional gene in nk cell defiency states, not sure but i think this type of defiency state is a lack of nk cells, where in cfs there can be normal amount of nk cells but they just dont work?? But u would think that all the co-infection that go with it would be the same??
    good link allby.
     
  5. searcher

    searcher

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    Hi allyb- That's a good question. I am not a scientist but have a biology background, so hopefully someone will correct me if I make a mistake. A single gene mutation is something you are born with and is passed down from your parents. So the deficient states talked about in heapsreal's link are not caused by herpes viruses. But our situations could be different, since as far as we know CFS patients weren't born with deficient NK cells (although I suspect we don't know that for sure.) The only researcher I have discussed this with thinks that the low NK cell function is the reason for herpes viruses going crazy, and that there is another underlying cause for the NK cell dysfunction. I think figuring out the cause of the NK cell dysfunction will be they key to this illness.
     
  6. floydguy

    floydguy Senior Member

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    Genetic pre-disposition to low perforin?
     
  7. allyb

    allyb Senior Member

    Thanks heapsreal,
    I read somewhere but cant remember where that the herpes virus affects the memory of the NK cell, so to speak?

    Thank you searcher, I am trying to understand this and make it relevant to me to do so.

    This would make sense because I never caught anything until I had an open mouth wound in hospital last year in my late 40is until then I was as fit as could be. Surly if I had a deficiency I would had caught other things before this and suffered poor health, wouldnt I??

    It would seem like I had a highly effective immune for 48years

    This would seem to make sense to me (a simple soul)
    But it cant be detected so our tests are clear...... right?

    Are our T cells compromised in ME/CFS?

    Floydguy

    What is perforin and please could you explain it.
     
  8. merylg

    merylg Senior Member

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  9. globalpilot

    globalpilot Senior Member

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    Rodney Dietert is a toxicologist and has taken an interest in immune system dysfunction and CFS and particularly what agents disrupt immune dysfunction. There is a table here listing the different dysfunctions and agents known to cause the dysfunction.

    http://www.cfids-cab.org/rc/Dietert.pdf



     
  10. globalpilot

    globalpilot Senior Member

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