1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Can You Come for a Visit? My ME/CFS Says No
My daughter and son-in-law just had a baby last week. We are thrilled. But we won't be able to see the baby or hold her any time soon. We won't be able to take over little gifts or help out with housework or babysitting.
Discuss the article on the Forums.

Nitrous oxide side effects in PWME's

Discussion in 'Other Health News and Research' started by LaurelW, Jul 28, 2012.

  1. LaurelW

    LaurelW Senior Member

    Messages:
    552
    Likes:
    92
    Utah
    I had some dental work done three days ago and consented to have nitrous oxide for the first time because I've been pain-sensitive lately. It really helped with the procedure, but I've been spacey and nauseated ever since. It seems that the general consensus is that it wears off within minutes, but that doesn't seem to be the case with me. Do we react differently to this drug for some reason? Anything I can do at this point to lessen these symptoms?
    Thanks!
     
  2. Enid

    Enid Senior Member

    Messages:
    3,309
    Likes:
    841
    UK
    I've had to have major dental work done myself Laurel and being a little forewarned stayed only with injections - not too painful though. I'd suggest steer clear if you can it may take extra long to wear off.
     
  3. richvank

    richvank Senior Member

    Messages:
    2,717
    Likes:
    758
    Hi, Laurel.

    Nitrous oxide deactivates vitamin B12. People with ME/CFS have a functional B12 deficiency (according to the GD-MCB hypothesis as well as quite a lot of lab testing), so nitrous oxide can be expected to make this worse.

    I would suggest supplementing with vitamin B12. My preference is sublingual hydroxocobalamin at 2,000 micrograms per day, but if you have some other form on hand, either sublingual or ordinary oral, I would suggest going ahead and taking it.

    I don't recall whether you have tried the methylation treatment, but in the longer term, that can help to correct the functional B12 deficiency.

    Best regards,

    Rich
     
    ggingues likes this.
  4. LaurelW

    LaurelW Senior Member

    Messages:
    552
    Likes:
    92
    Utah
    Thanks, Rich. Does the brand matter? I haven't tried methylation treatment as I'm currently on Ampligen and it's helping, but I will probably try it once I go off to try to stay well.

    Enid, could you be more specific about how you were forewarned?
     
  5. richvank

    richvank Senior Member

    Messages:
    2,717
    Likes:
    758
    Hi, Laurel.

    I'm glad to hear that Ampligen is helping you.

    I think there are several good brands of B12 supplements. I favor the Perque B12 Guard, which is a sublingual hydroxocobalamin lozenge. But if you want quick relief, I would say take whatever B12 supplement you can easily get
    (or eat calf liver!)

    I hope you will be able to try the methylation protocol. It has helped most PWMEs who have tried it.

    Best regards,

    Rich
     
  6. Wayne

    Wayne Senior Member

    Messages:
    2,221
    Likes:
    1,373
    Ashland, Oregon
    leela and Helen like this.
  7. Helen

    Helen Senior Member

    Messages:
    575
    Likes:
    585
    Thanks @Wayne!
    I think most women know some other woman (-en) who got a post partum depression (after giving birth) or even a psychosis. If they had got B12 and folate treatment after the pain killing nitrous oxide they had probably stayed healthy. This is old knowledge but seems to have been forgotten by many doctors. I think we can guess some SNP´s of these poor women...
     
    helen1 and Wayne like this.
  8. knackers323

    knackers323 Senior Member

    Messages:
    885
    Likes:
    177
    Are nitrous oxide and nitric oxide the same thing? If so I am pretty sure this is what a dr jay Goldstein was finding could often bring about almost immediate remission in cfs patients. I would love to try it but can't find an online source for it. Anyone know of one?
     
  9. valentinelynx

    valentinelynx Senior Member

    Messages:
    194
    Likes:
    68
    Tucson
    No, sorry nitrous oxide and nitric oxide are not the same thing! Nitric oxide is produced in the body. It is plays many roles, some good, some bad. It is a free radical, and a cellular signaling molecule. The only medical use I know of for pure nitric oxide (which is a gas) is for pulmonary hypertension, but it is very rare and expensive.

    As far as ME/CFS goes, Dr Martin Pall has a theory called the NO/ONOO theory that involves the role of NO and free radicals in this illness and related ones such as MCS. It is a complex theory. He proposes a number of supplements that can influence the process. See: http://www.thetenthparadigm.org/mcs09.htm

    I'm not sure what you are thinking of in regard to Dr Goldstein. I was a patient of his years ago. He did use a number of NMDA antagonists (such as ketamine) with good result. Perhaps that's what you are thinking of? I seriously doubt he had access to nitric oxide gas. We couldn't even get it for a high risk surgery for a patient with severe pulmonary hypertension in an academic hospital (back in the early 2000s).
     
    Helen likes this.
  10. knackers323

    knackers323 Senior Member

    Messages:
    885
    Likes:
    177
    Hi yes I was thinking of nitro glycerine. Did you try this? I've heard he got good results with it.

    Can I ask what else you tried with him? Thanks
     
  11. leela

    leela Slow But Hopeful

    Messages:
    2,464
    Likes:
    3,043
    Couchland, USA
    Long before I got ME I would refuse nitrous oxide at the dentist, because it made me feel nauseous and, paradoxically, very anxious. It always felt immediately really toxic, before I was sick or knew about any of this stuff, so I reckon the whole methylation theory is proving itself right there.
     
    Helen likes this.
  12. Helen

    Helen Senior Member

    Messages:
    575
    Likes:
    585
    Thanks for a great link. There are also lots of interesting facts about genetics , mercury and other toxins a.o.
     

See more popular forum discussions.

Share This Page