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Nitric Oxide: Good or Bad, High or Low in CFS/ME?

Discussion in 'General Treatment' started by Lotus97, May 25, 2013.

  1. Lotus97

    Lotus97 Senior Member

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    There was a thread started about this in the Methylation/Chelation forum, but since not everyone follows that forum and the General Treatment forum I thought it would be a good idea to start a thread about it here also. I think everyone is in agreement that peroxynitrite is bad. It's been suggested that increasing nitric oxide (NO) would be bad because it could lead to more peroxynitrite (ONOO), but I don't know if there's any consensus about whether or not it would be a good idea to take supplements that increase nitric oxide.
  2. Lotus97

    Lotus97 Senior Member

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    I'm confused by this person's article. They quote Dr. Pall, but then conclude that taking arginine is a good thing. I haven't read the whole article, but these are the sections I'm referring to:
    http://www.naturdoctor.com/Chapters/Research/CFS.html

  3. Lotus97

    Lotus97 Senior Member

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    Someone posted this article about Dr. Pall in another thread:
    http://www.prohealth.com/library/showarticle.cfm?libid=12896

    My response was the same as AFCFS
  4. kyzcreig

    kyzcreig

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    This is a good post. It's true, perhaps NO isn't the problem as much as a dysregulation of the ONOO cycle, leading to potentially too much peroxynitrate and iNOS while eNOS and nNOS are depressed.
  5. peggy-sue

    peggy-sue

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    NO itself only ever exists for nanoseconds (or less).

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