Both of these articles are about how inhibition of nNOS and eNOS and potential overstimulation of iNOS could be mechanisms underlying specific symptoms of ME/CFS. Just how hypothetical is this overproduction of iNOS, I wonder? My NOS2 snps, I am told, are downregulations. I suspect that would be one reason my EBV antibodies are in the stratosphere (22 years after having infectious mono). I can't be the only person here with a high viral load, either. A very interesting read, nonetheless. I'm starting to understand nitric oxide a little better. Thank you, Andrew!