From Mariam Emr, On behalf of the Trans-NIH ME/CFS Working Group The slides from the NIH presentation at the IACFSME meeting in Ft. Lauderdale, Florida have been posted. You can view the slides at https://www.nih.gov/sites/default/files/research-training/initiatives/mecfs/whittemore-presentation.pdf Short version (my take) Long-term (FY18-22) it's much as you'd hope Though I'm a little disappointed that new RFAs doesn't seem to be a priority til then "Develop new RFAs as appropriate" as current RFA plans are around building infrastructure and research capacity, not directly funding studies. Medium term (FY17-18) Well, that certainly seems to be the meat of it, though it's not at all clear this will involve RFAs to spur research until they are 'considered' in 2018. Also: • Encourage Investigator-initiated grants submitted through parent grant announcements [ anyone explain this??] • Encourage submission of applications from young investigators to develop pipeline of investigators Also Work with FDA to develop clearly defined endpoints for treatment trials and interventions Develop mechanisms for access to available biospecimensfor potential identification of biomarkers Launch ME/CFS Collaborative Research Centers and ME/CFS Data Management and Coordinating Center Foster and develop international collaborations and partnerships to foster ME/CFS research Assess clinical trial readiness and potential treatment and intervention trials for ME/CFS Leverage CDC health care provider educational materials Short-term included the request for information to help establish research priorities (which will presumably be announced at some point) - and focusing on "Common data elements" for all studie (a CDC priority too), which will help multiple centers work together in building longitudinal cohorts. I hope these will include developing one for PEM, whih hasn't yet been defined well by anyone (as a questionnaire for patients). I thought this was quite promising overall, and a long way forward from where things stood a couple of years back. But read the slides yourself and make up your own mind.