http://grants.nih.gov/grants/guide/pa-files/PA-08-246.html#SectionI "Mangan's imprint is definitely on this. Check out the inclusion of ME...They also emphasis microbrial infections...At one point in the last decade the NIH basically said we're not studying pathogens anymore. There is a definite focus on intersystemic signaling - how the different systems of the body talk to each other. They have focused on that for quite a while. I like his idea to try and ally ME/CFS with other disorders - although we'll see how that turns out. There is also a focus on gender; I think its a good idea to look at why women are more like to get ME/CFS and FM and,,,.,..a focus on subsets, I've never seen the desire to control for phase of the menstrual cycle....I imagine this has something to do with the 'subtle perturbations' mentioned and the fear that the menstrual cycle will swamp them....it seems a bit much, though to ask a researcher to do that....that's alot of work to make sure your participants are 'in phase'. I like this because it gets us an entree into other disorders funding Never seen 'clock related genes' before - This is one of my favorites It like all federal announcements of this type is very broad and there will be things in here that are objectionable to some; that is expected and there's alot of good in here. The proof is in the pudding and what kind of studies they end up funding.