NIH Funding Studies On Normal Molecular Responses To Exercise

[Never Give Up]

This should benefit ME/CFS research- you have to know what is normal to know what is not.

https://www.nih.gov/news-events/new...nd-molecular-changes-during-physical-activity

The National Institutes of Health Common Fund announced today the first awards for the Molecular Transducers of Physical Activity in Humans Program, which will allow researchers to develop a comprehensive map of the molecular changes that occur in response to physical activity. Nineteen grants will support researchers across the country to collect samples from people of different races, ethnic groups, sex, ages, and fitness levels. The samples will be analyzed to uncover how physical activity changes the chemical molecules within our bodies

 

[Denise]

This should benefit ME/CFS research- you have to know what is normal to know what is not.

https://www.nih.gov/news-events/new...nd-molecular-changes-during-physical-activity

This is interesting. Thanks for posting it.
Once they establish what changes are normal during activity, they have to see if people with well-studied diseases/conditions also have normal responses... in addition to looking at responses in people with ME.

They also need to establish things like:
Does the range of normal change with age?
Does the range change as a result of frequency/intensity of activity?

 

[Gemini]

This should benefit ME/CFS research- you have to know what is normal to know what is not.

Thanks for posting this, @Never Give Up.

Relevant to PEM/PENE. Perhaps MECFS cohorts could be included as "abnormal controls" by the impressive consortium that has been organized to carryout this research: $170 million in NIH funding(19 NIH grants).

Michael Synder at Stanford who is working with Ron Davis is involved and all of the NIH Institutes--NIASM, NIDDK, NIA, NIBIB-- are members of the Trans-NIH MECFS Working Group. @Ben Howell, any thoughts?

Clinical Centers
MoTrPAC investigators will recruit approximately 2700 healthy adults for an exercise study. They will collect blood, urine, and tissue samples from active and sedentary volunteers who will perform resistance or aerobic exercises. The adult Clinical Centers are led by
· Marcas Bamman at the University of Alabama at Birmingham Center for Exercise Medicine, Bret Goodpaster at the Translational Research Institute for Metabolism and Diabetes in Orlando, Florida, and Scott Trappe at the Ball State University Human Performance Laboratory (U01AR071133)
· John Jakicic at the University of Pittsburgh (U01AR071130)
· Wendy Kohrt at the University of Colorado, Denver (U01AR071124)
· William Kraus at Duke University, in partnership with Joseph Houmard at East Carolina University and Barbara Nicklas at Wake Forest Baptist Medical Center (U01AR071128)
· Blake Rasmussen at University of Texas Medical Branch at Galveston and Nicolas Musi at the University of Texas Health Science Center at San Antonio (U01AR071150)
· Eric Ravussin and Tuomo Rankinen at Louisiana State University’s Pennington Biomedical Research Center (U01AR071160)
Another Clinical Center (U01AR071158), led by Dan Cooper and Shlomit Radom-Aizik at the University of California-Irvine, will focus on the molecular changes that occur when children and adolescents exercise.

Chemical Analysis Sites
Investigators at seven Chemical Analysis Sites will extensively analyze the human and rodent samples using various genomic, epigenomic, transcriptomic, proteomic, and metabolomic, technologies. The teams are led by
· Joshua Adkins at Pacific Northwest National Laboratory (U24DK112349)
· Charles Burant and Jun Li at the University of Michigan (U24DK112342)
· Robert Gerszten, Clary Clish, and Stephen Carr at the Broad Institute/Beth Israel Deaconess Medical Center and Chris Newgard at Duke University (U24DK112340)
· Dean Paul Jones at Emory University (U24DK112341)
· Sreekumaran Nair and Ian Lanza at Mayo Clinic, Rochester (U24DK112326)
· Stuart Sealfon and Martin Walsh at Icahn School of Medicine at Mount Sinai (U24DK112331)
· Michael Snyder and Stephen Montgomery at Stanford University (U24DK112348)

Bioinformatics Center
The Bioinformatics Center (U24EB023674), led by Euan Ashley at Stanford University, is responsible for establishing standards and protocols for data acquisition and storage, providing analytic tools for integrating and interrogating data generated through the Chemical Analysis Sites, and developing a user-friendly database that any researcher can access to develop hypotheses regarding the mechanisms whereby physical activity improves or preserves health.

Consortium Coordinating Center
The Consortium Coordinating Center (U24AR071113), led by Marco Pahor at the University of Florida, Michael Miller at Wake Forest Baptist Medical Center, Walter Rejeski at Wake Forest University, and Russell Tracy at the University of Vermont, will manage study protocol development and implementation and will coordinate the collection and distribution of data and biological samples during the project. It will organize, monitor, and support the MoTrPAC Steering Committee and any subcommittees that the Steering Committee may establish to ensure that all aspects of the clinical and animal protocols and the analysis plans contribute to the mapping of molecular changes in response to exercise.

 

[*GG*]

Interesting, hope I can donate my blood and be included! Could travel to Burlington, VT or the State of MA if necessary!

GG