Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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NIH awards 'supplemental grants' to Lipkin, Katz, Fletcher, other big names

Discussion in 'General ME/CFS News' started by Simon, Oct 12, 2016.

  1. Simon

    Simon

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    Update via email from Marian Emr, Communications Director, NINDS

    The NIH has awarded seven administrative [mecfs] supplement grants in response to a Notice of Availability that was issued in April 2016. Awarded supplements will enable NIH-funded projects to expand the collection and analysis of biospecimens from individuals with ME/CFS to aid in biomarker identification and help identify potential therapeutic targets.

    Also note
    The Trans-NIH ME/CFS Working Group will be hosting a telebriefing on Wednesday, November 2, 2016 from 3:00-4:00pm EDT. The purpose of this call will be to offer updates on NIH’s recent activities related to ME/CFS and provide an opportunity for the community to ask questions. Call-in details will be available shortly.

    Unfortunately it's not clear how much was awarded, or exactly what for (descriptions may be for the original study, not just the 'supplemental' bit, but here are the details
    " More details about the awarded supplements are available at https://www.nih.gov/mecfs/funding under “Funded Projects.” "

    NOVA Southeastern University
    • Lubov Nathanson, gene expression in response to exercise

    • Mary A. Fletcher,
      Gender differences in responset to exercise
    Looks like this will collect new samples from men, to compare with ones already collected for women


    • Louis Nacul, London School of Hygeine and Tropical Medicine, A longitudinal immunological and virological study for ME CFS biomarker discovery
    This looks like new funding to allow collection of samples from patients at additional timepoints for the UK mecfs biobank


    • Ben Katz/Lenny Jason, A prospective study of CFS following infectious mononucleosis in college students
    I've no idea what the new element of this is



    • Mark Davis, Stanford. Adaptive and innate immunity, memory and repertoire in vaccination and infection
    This looks to me like it might be funding for part of the OMF severely-affected study, as that too looks at T-cell receptors in detail, but maybe it's looking at a new aspect of T cell receptors.

    • Ian Lipkin, Columbia, Center for Research in Diagnostics and Discovery
     
    Last edited: Oct 12, 2016
  2. Valentijn

    Valentijn The Diabolic Logic

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    They all look like excellent research projects :)
     
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  3. PNWMom

    PNWMom

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    Cool! My daughter's blood sample is going into the Lipkin project. Nice to know what it is specifically :)
     
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  4. snowathlete

    snowathlete

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    I hope this is the begining of a new wave of funding for decent looking, appropriate, biomedical research.
     
  5. Mary

    Mary Senior Member

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    Wow - so glad to hear this!!! :thumbsup::)
     
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  6. BurnA

    BurnA Senior Member

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    Its great to see Mark Davis get involved - definitely a result of Ron Davis' work.

    Ian Lipkins work sounds fascinating, do we know what the status of that research is ?

    ETA Any speculation as to what the telebriefing might be about - will we learn anything new ?
     
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  7. leela

    leela Slow But Hopeful

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    Thank you @Simon, it's always wonderful to hear good news! Sea change afoot!
     
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  8. Thomas

    Thomas Senior Member

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    This will be really interesting to me -- seeing as a flu shot triggered my ME. I wonder if various types of triggers require different types of treatment. Navieux's recent paper suggested no. However, I'm unaware if Fluge and Mellas recent lecture in Norway that was posted here elsewhere feel that different triggers require different treatments.
     
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  9. Tuha

    Tuha Senior Member

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    I dont know but can additional 100 000 USD to each study help the researchers to move their studies significantly? I dont have this impression. Research is very expensive. Maybe they can make few more additional tests or add some more patients but nothing significant. It´s certainly a small step forward but we need much more to move faster.
     
  10. RogerBlack

    RogerBlack Senior Member

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    'no' - but maybe.
    Often a fairly modest increase in patients sampled can dramatically improve the statistical power of a study. As can adding subgroups - for example a FM/normal trial - adding a CFS arm to it, may not add much cost in some cases, but can get lots more useful data out.
     
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  11. Simon

    Simon

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    Helpful summary and extra info from Cort ($100k per supplemental grant, appaarently), Marueen Hanson is in there too

    Taking Stock: the NIH and Chronic Fatigue Syndrome (ME/CFS) - Health Rising

    Supplemental Funding Program Is Working A couple of months ago the NIH added

    A couple of months ago the NIH added supplemental funding of about $100,000 each for chronic fatigue syndrome projects already underway. The good news is that major Institutes such as NINDS (nervous system) and NIAID (immune) supported it. The bad news is that major institutes such as NIAMS (rheumatology), NHLBI (heart/lung), NIDDK (diabetes) and others didn’t. Of the fifteen Institutes in the Working Group five participated.

    The NIAMS drop out meant that money wasn’t available to add ME/CFS cohorts to some FM studies. If this small project was a litmus test for Institute support it didn’t go so well.

    With seven studies receiving approximately an extra $100,000 in funds each, the supplemental funding program, however, appears to be something of a success.The funding will help:

    • Dr. Fletcher and Dr. Nathanson at NSU will determine if men with ME/CFS respond differently to exercise than women and will explore the interaction between genetics and exercise. (It appears that the extra money allowed Dr. Fletcher to add men to a formerly all female exercise study.)
    • Dr. Nacul in London will use the extra money to help him compare immune, viral and genetic markers over time in ME/CFS and MS.
    • Dr. Katz and Lenny Jason will try to determine why some college students with mononucleosis are prone to develop ME/CFS.
    • Drs. Campagne and Maureen Hanson of Cornell will look for changes in the gene expression of immune cells
    • Stanford’s big immune researchers, Dr. Mark Davis will use new technologies to take a closer look at T-cells than has ever been done before
    • Dr. Ian Lipkin of Columbia will determine what pathogens ME/CFS patients have been exposed to in the past.
     
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  12. aimossy

    aimossy Senior Member

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    I'm contributing a deflated yay about this to be honest. Universities usually also take a reasonable percentage cut off from any grants too. So that means the direct amount received is lower.
     
    Last edited: Oct 13, 2016
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  13. Jenny TipsforME

    Jenny TipsforME Senior Member

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    This is good news.

    Slightly random thought occurred to me while reading: in terms of gender difference has anyone looked at whether it is the same proportional difference at onset? I'm wondering if the metabolic gender differences Naviaux picked up might mean more men recover? Seeing as ME just goes on and on for years this could easily make it look like 4x as many women get it, rather than that fewer women recover. Just a random question.
     
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  14. boohealth

    boohealth Senior Member

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    Re:vaccinations I believe they need to look at the presence/type of adjuvant. In healthy gulf war vets (under Bush 1), adjuvants were used because there was not enough vaccine to go around. And a portion got permanently ill. There was a whole, well researched book about it.

    The adjuvants stimulate a stronger immune response, but I think the combo of vaccine and adjuvant may throw some immune systems into overdrive and autoimmunity or hypersensitivity to either that vaccine sequence and/or generally.,
     
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  15. Gemini

    Gemini Senior Member

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    @Simon, by any chance do you know the Call-in details for this Nov 2nd telebriefing?
     
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  16. moosie

    moosie

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    I know I have no brains but the dates on this seem a bit odd It's 02-11-2016 today isn't it? The heading above says 12-11-2016 and some of posts 13-11-2016. Or did I sleep through a whole 10 days?

    Edit -
    I'm a fool. What am I? It's November (11) not October (10) . . . or something.
    As you were.
     
    Last edited: Nov 2, 2016
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  17. Nielk

    Nielk

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    Yes - it's today. It's supposed to be starting I half an hour but, I have not seen any call in details.
    Anyone know more?
     
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  18. Nielk

    Nielk

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    Someone just gave me the following info they received in an email:

    Due to interest in tomorrow’s call, we have set up a new conference line. If you will be calling from the U.S., please use the following dial-in information for the telebriefing.



    Dial-in: 866-844-9416

    Participant passcode: 8048800
     
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  19. Nielk

    Nielk

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    Starting in five mins.
     
  20. Nielk

    Nielk

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    Dr. Koroshetz is briefly describing what NIH does. mission id to- seek knowledge of living systems and diseases and enhance health and life and reduce disability This is what NIH is trying to do for ME/CFS.

    NIH is made up of 27 institutes and centers. they receive their budget from congress.

    Most funds got out to outside investigators via grants. Some investigations are in house - intramural.
     
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