1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Can You Come for a Visit? My ME/CFS Says No
My daughter and son-in-law just had a baby last week. We are thrilled. But we won't be able to see the baby or hold her any time soon. We won't be able to take over little gifts or help out with housework or babysitting.
Discuss the article on the Forums.

Nicolson 2014 - Use of Natural Supplements to Improve Mitochondrial Function (CFS)

Discussion in 'Latest ME/CFS Research' started by Bob, Feb 7, 2014.

  1. Bob

    Bob

    Messages:
    7,960
    Likes:
    9,930
    England, UK
    I don't think this has been posted yet.

    Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.
    Garth L. Nicolson, Robert Settineri and Rita R. Ellithorpe
    Functional Foods in Health and Disease 2014; 4(1):23-65
    Publication date: January 25, 2014

    Full paper available here:
    http://functionalfoodscenter.net/files/81845995.pdf

    This paper is a review of various studies that have tested health supplements for a variety of fatiguing illnesses, including CFS.

    There are a grand total of 319 references in this paper! A special Phoenix Rising prize goes to the first person who reads them all!

    The review suggests that there have been substantial reductions in fatigue in CFS patients after some of these supplements were prescribed. But the devil is in the detail i.e. the methodology of the reviewed papers. i.e. were there control groups?

    I've only checked one of the reviewed papers (see next post), which does not have a control group, but I suspect that they are mostly, or entirely, low-powered and without an adequate control group.

    Last edited: Feb 7, 2014
  2. Bob

    Bob

    Messages:
    7,960
    Likes:
    9,930
    England, UK
    This an example of one of the papers it reviews, which 'coincidentally' happens to be by the same authors:

    Lipid Replacement Therapy with a glycophospholipid formulation with NADH and CoQ10 significantly reduces fatigue in intractable chronic fatiguing illnesses and chronic Lyme disease patients.
    Nicolson GL, Settineri R, Ellithorpe E.
    Intern J Clin Med 2012; 3(3): 163-170.
    http://file.scirp.org/Html/2-2100271_19382.htm

    I've checked it out and it has no control group.
    Last edited: Feb 7, 2014
    Helen, aimossy and Esther12 like this.
  3. Soundthealarm21

    Soundthealarm21 Senior Member

    Messages:
    230
    Likes:
    193
    Dallas, TX
    Not far into it, but have seen tremendous improvement with lipid replacement therapy so far.
  4. Esther12

    Esther12 Senior Member

    Messages:
    5,184
    Likes:
    5,182
    Maybe this shows I'm really biased and unreasonable, but I have to admit toa certain instinctive scepticism of papers that talk about 'natural supplements'. Thanks for having a look anyway... no control group is generally a good reason for scepticism!
    barbc56 and Bob like this.
  5. August59

    August59 Daughters High School Graduation

    Messages:
    1,480
    Likes:
    404
    Upstate SC, USA
    I've taken 10mg of NADH and 200mg of CoQ10 for about a year without any measurable benefits. However, it was shortly after this that I found out that I had very high EBV and significantly high HHV-6 titres. This could have very well been cancelling out any improvements!

    I think anyone that has been ill for an extended period of time is going to have some level of mitochondrial dysfunction.
    Radio likes this.
  6. Helen

    Helen Senior Member

    Messages:
    468
    Likes:
    411
    Me too, thanks to @Radio who posted about this earlier.
    Soundthealarm21 and Radio like this.
  7. adreno

    adreno 3% neanderthal

    Messages:
    2,271
    Likes:
    1,385
    Tundras of Europa
    Using NT factor or regular phosphatidylcholine?
  8. Soundthealarm21

    Soundthealarm21 Senior Member

    Messages:
    230
    Likes:
    193
    Dallas, TX

    Body Bio phosphatidylcholine, VSL3 and others
    Radio likes this.
  9. Radio

    Radio *****

    Messages:
    453
    Likes:
    243
    I am fully recovered from CFS :woot:

    Repairing the mitochondria, we allow our cells to increase their nutrient uptake so that supplementation support will have the most dramatic effect.


    The key to my recovery was...

    1. Super clean diet (The low histamine Chef Diet) + Organic rice...No coffee, No table salt...Just Eat Real Food...

    2. Phospholipid Replacement therapy

    3. Supporting mineral deficiencies

    4. Methylation Support, <---(last step), Also, Limit P5P (pyridoxal-5-phosphate) inhibits PST (phenol sulphur-transferase) activity.
    Last edited: Feb 9, 2014
  10. CFS_for_19_years

    CFS_for_19_years Senior Member

    Messages:
    238
    Likes:
    206
    Washington State
    @Bob On page 20, there were healthy control groups AND a crossover study:

    "In a subsequent cross-over study the effects of LRT on fatigue and mitochondrial function
    were monitored in patients with moderate to severe chronic fatigue [212]. There was good
    correspondence between reductions in fatigue and gains in mitochondrial function. After 8
    weeks of LRT with NTFactor, mitochondrial function was significantly improved, and after 12
    weeks of NTFactor supplementation, fatigue was decreased by 35.5% (p<0.001), and
    mitochondrial function was found to be similar to that found in young healthy adults (26.8%
    increase, p<0.0001) [212]. After 12 weeks of supplement use, subjects were placed on placebo
    for an additional 12 weeks, and their fatigue and mitochondrial function were again measured.
    After the placebo period, fatigue and mitochondrial function were intermediate between the
    initial values and those found after 8 or 12 weeks on the supplement, indicating that continued
    supplementation is required to show improvements in mitochondrial function and maintain lower
    fatigue scores [212]."

    I'm done quoting for a while. I've got my NT Factor Lipids on my kitchen counter beckoning to me.
    Bob and Soundthealarm21 like this.
  11. CFS_for_19_years

    CFS_for_19_years Senior Member

    Messages:
    238
    Likes:
    206
    Washington State
    I have no improvement in fatigue or anything else after taking NT Factor for 11 weeks. I must be a hard case.:depressed:
  12. Martial

    Martial Senior Member

    Messages:
    757
    Likes:
    507
    Ventura, CA
    Well it may help the mitochondria for protection and healing, but if there are no improvements then perhaps there is an active infection of some kind that is still contributing to mitochondrial dysfunction and needs to be addressed as well?
    Radio likes this.
  13. CFS_for_19_years

    CFS_for_19_years Senior Member

    Messages:
    238
    Likes:
    206
    Washington State
    Your guess is as good as mine. I'm sure there's plenty that needs to be addressed!
  14. Martial

    Martial Senior Member

    Messages:
    757
    Likes:
    507
    Ventura, CA
    Lol! Well I have the same issue so I feel ya..
  15. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    3,284
    Likes:
    3,712
    Cornwall, UK
    The patients were 'aged' people suffering from fatigue, and the paper states that decreased mitochondrial function is a characteristic of aging and fatigue.

    I don't think that age-related mitochondrial dysfunction is the same as ME-related mitochondrial dysfunction.

    I only had a quick look at the paper (reference 212, and found through an internet search) but it didn't seem to be controlled in in the usual sense.
  16. Martial

    Martial Senior Member

    Messages:
    757
    Likes:
    507
    Ventura, CA
    It is still helpful to supplement and support the michondria for support, and because there is such a heavy assault from chronic pathogens as it is. The source may not be the same in both cases but the benefits are still very high in both cases. Though in CFS it would be more important to treat these underlying etiologies as well. Mitochondrial dysfunction is just part of being in a state of disease, the complications on ATP production and the energy house of the immune system seems to always come into play. Supporting all the unique passageways and finding what works for each individual will probably be helpful in the cases unrelated to stress of aging, etc.

    Methylation mutations, genetic pre dispositions, nutritional re balancing, finding specfic viral and bacterial loads, there is so many possibilites and options out there sometimes I just get excited thinking of all the cool research that can be done, and things that people can try out seems so cool! Never would you have so much access to all of this, and so many tools to work with say, like thirty years ago.

See more popular forum discussions.

Share This Page