@
lift:
I think it's a problem with definitions... What is over-methylation exactly?
Maybe you're right, all I can say is that I have no evidence that symptoms of excessive anxiety correlate with over-methlyation.
Why? Because I went through a period of very strong, almost intolerable anxiety taking sublingual methylfolate. I kept going for 6 weeks trying to modulate the dosage (800-1000mcg max) so that the anxiety wouldn't go out of control.
When I tested my homocysteine level again it was almost the same value (actually worse) than I had before, when I was taking a smaller oral dose. Same high homocysteine level = same crappy methylation.
Now I can tolerate higher doses of methylfolate and methyl-B12 and still my Hcy levels are sub-optimal and my glutathione and sam-e are below range, meaning
under-methylation.
If I was over-methylating I would have expected the labs to show it. E.g. moderate/high values of glutathione/sam-e and low or very low Hcy levels.
Maybe other people here use the same label,
over-methylation, for something else, but I am not sure if it's really correct. I think those are just methyl-folate side effects.
Additionally people with a true over-methylator profile (e.g. Hcy < 6) don't necessarily suffer of horrible anxiety, so I am really not sure that this label is accurate.
That's my 2c. I'd like to hear what other people think.
Has anyone else checked their labs when they had these sorts of symptoms to see if there was anything different in their methylation?
cheers