I currently take 100mg of Niacin three times a day. It seems to have a calming effect which I like. I'm adding methylation related supplements based on my test results from yasko. There seems to be some hint that niacin renders methyl donors ineffective (http://mthfr.net/overmethylation-and-undermethylation-case-study/2012/06/27/). What is the consensus on taking Niacin regularly - is in going to interfere with methylation support?