After noticing some pretty good improvements after 3 months on daily methyl B12 sub cut injections i decided to look into B12 deficiency and Pernicious Anemia more closely. On my journeys around Google i stumbled on the work of Dr Chandy, an NHS GP who believs that Vit B12 deficiency is very common and treats 700 of his patients with it, with remarkable results. He has been threatened at one point with being struck off, but has since been allowed to continue his work, on the NHS. Dr Chandy believes that some cases of M.E and M.S could be end stage diseases of B12 deficiency, he also discusses functional B12 deficiency. The website that has been set up by his supporters is very good, with lots of info if you trawl through it. This is an old interview from the website, filmed by the BBC http://b12d.net/content/bbc-documentary-and-testimonials All the best, Justy.