Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
Simon McGrath provides a patient-friendly version of a peer-reviewed paper which highlights some of the most promising biomedical research on ME/CFS ...
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NGF mediated sympathetic sprouting

Discussion in 'General Symptoms' started by Emootje, Nov 16, 2013.

  1. Emootje

    Emootje Senior Member

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    Nerve growth factor (NGF) is a growth factor that supports the development and survival of sensory and sympathetic neurons. NGF causes pain. NGF levels are elevated in several conditions in humans, including fibromyalgia, complex regional pain syndrome, arthritis, interstitial cystitis, polycystic ovary syndrome, PTSD, and chronic headaches. NGF-evoked hyperalgesia is partly mediated through a sympathetic-sensory interaction. Dr. Martinez-Lavin hypothesized that fibromyalgia is a sympathetically maintained pain syndrome caused by NGF mediated sympathetic sprouting, a COMT deficiency and a SCN9A sodium channel gene variant.
    Martinez-Lavin.JPG
    http://www.hindawi.com/journals/prt/2012/981565/

    NGF is unregulated by inflammatory mediators (IL-1, TNF alpha, prostaglandins, leukotrienes, histamine).
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737061/pdf/1744-8069-9-37.pdf
    http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0701313/pdf
    http://www.sciencedirect.com/science/article/pii/S0304395998001146

    Now I was wondering if there is a (natural) way to lower NGF, any ideas?
    (Tanezumab (anti-NGF) and Stellate ganglion block are options but not achiveble for me)

     
  2. leela

    leela Slow But Hopeful

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    Thanks for this; very interesting.
    Can you provide a link to that helpful chart? It won't save to my desktop and I don't see it in any of the links you provided.
     
  3. Emootje

    Emootje Senior Member

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    Last edited: Nov 17, 2013
  4. leela

    leela Slow But Hopeful

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    Dankuwel, Emootje :angel:
     
  5. Emootje

    Emootje Senior Member

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