NGF mediated sympathetic sprouting

[Emootje]

Nerve growth factor (NGF) is a growth factor that supports the development and survival of sensory and sympathetic neurons. NGF causes pain. NGF levels are elevated in several conditions in humans, including fibromyalgia, complex regional pain syndrome, arthritis, interstitial cystitis, polycystic ovary syndrome, PTSD, and chronic headaches. NGF-evoked hyperalgesia is partly mediated through a sympathetic-sensory interaction. Dr. Martinez-Lavin hypothesized that fibromyalgia is a sympathetically maintained pain syndrome caused by NGF mediated sympathetic sprouting, a COMT deficiency and a SCN9A sodium channel gene variant.

http://www.hindawi.com/journals/prt/2012/981565/

NGF is unregulated by inflammatory mediators (IL-1, TNF alpha, prostaglandins, leukotrienes, histamine).
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737061/pdf/1744-8069-9-37.pdf
http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0701313/pdf
http://www.sciencedirect.com/science/article/pii/S0304395998001146

Now I was wondering if there is a (natural) way to lower NGF, any ideas?
(Tanezumab (anti-NGF) and Stellate ganglion block are options but not achiveble for me)

 

[leela]

Thanks for this; very interesting.
Can you provide a link to that helpful chart? It won't save to my desktop and I don't see it in any of the links you provided.

 

[Emootje]

Thank you Leela. The chart becomes only visible in the PDF file of the above-mentioned article:
http://downloads.hindawi.com/journals/prt/2012/981565.pdf
Dr. Martinez-Lavin uses the same chart in this article:
http://arthritis-research.com/content/pdf/ar2146.pdf
Link to the chart:
http://arthritis-research.com/content/9/4/216/figure/F1?highres=y

 

[leela]

Dankuwel, Emootje

 

[Emootje]