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Next steps after receiving MTHFR information

Sparrowhawk

Senior Member
Messages
514
Location
West Coast USA
Yes.
My MTHFR specialist has me on calcium folinate (folinic acid) ie bioactive form of folic acid. I used to take regular folate before due to a specialist not realising we need an active form of folate and that didnt do a thing, this other form does help me. My specialist says I should never have been put on normal form of folic as those with this MTHFR cant use that form well.



With one of the MTHFR issues you have at least, I know you need the methylB12 form for that as you need the methyl group. I do have an drawing of how this works with the methylB12 which my specialist copied for me, I'll find and post it here for you some time so you can understand this polymorphism better and where the methylB12 plays into it etc
Excellent! I will look forward to seeing that and appreciate all the great information above. I have learned a ton in just two days, not trying to rush this but I can see how some of you who have done this more than a year really have a grip on the many variables, esp. wrt your own SNPs.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
what is BH4?
BH4 is tetrahydrobiopterin. It has a lot of functions, like converting tryptophan to 5-HTP on it's way to becoming serotonin and converting phenylalanine to tyrosine to dopamine. It's also used to turn arginine into NO, which takes two molecules of BH4. If BH4 is in short supply, arginine instead produces peroxynitrite or super oxide, both of which lead to oxidative inflammatory disease, according to Heartfixer.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
There is a specific test for leaky gut, I think it's called an intestinal permeability test. For the test you drink two different sugars, each with different sizes molecules, one larger and one smaller. Then they measure how much of each molecule makes it to your urine. If the larger molecules are getting waylaid and not showing up in your urine, then you have leaky gut.
Thanks, Caledonia.
I was just reading about that test. The small molecules are supposed to get through. If the large molecules make it to your urine, they went through the leaky gut wall (instead of ending up in feces where they belong). They look at the ratios to determine degree of leakiness.
 

caledonia

Senior Member
Thanks, Caledonia.
I was just reading about that test. The small molecules are supposed to get through. If the large molecules make it to your urine, they went through the leaky gut wall (instead of ending up in feces where they belong). They look at the ratios to determine degree of leakiness.

Thanks, had it backwards. That's what I get for doing things from memory instead of looking them up. :oops:
 

taniaaust1

Senior Member
Messages
13,054
Location
Sth Australia
Excellent! I will look forward to seeing that and appreciate all the great information above. I have learned a ton in just two days, not trying to rush this but I can see how some of you who have done this more than a year really have a grip on the many variables, esp. wrt your own SNPs.

I havent had the 23andME test done yet but got my MTHFR polymorphism picked up on a different genotype test which only looked for a few gene things which caused abnormal clotting, I hope to have the 23andME test done soon so I guess I will be then like you and trying to figure out all the rest of the things which come up. Its good to see others trying to help you to understand your results as I will be needing advice soon.

Here's the diagram of how MTHFR affects and where these things feed into the cycle.

MTHFRpolymorphismdiagram.jpg
 

Sparrowhawk

Senior Member
Messages
514
Location
West Coast USA
What a great diagram.

So if I am using up all my SAMe making adrenaline and cortisol, perhaps that's why I have no ATP...

I did realize yesterday that I should probably have posted this to the Genetic Testing and SNP's forum instead. It seems that's where most of these types of threads are housed.
 

helen1

Senior Member
Messages
1,033
Location
Canada
Mimi, where do you get your BH4 from? I've looked for it but the websites I saw needed a health care provider's number or didn't ship to Canada.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
I got mine from Nutrimedical.com.
I couldn't see whether they shipped to Canada because their website was slow tonight. Or maybe it was my connection. Anyway, I gave up. Check them out.