I just received my 23andMe info last night and ran it through Genetic Genie today. My detox pathway analysis looks pretty darn good, which surprises me, but I do have some red items on the Methylation pathway analysis. Gene & Variation rsID Alleles Result COMT V158M rs4680 AA +/+ COMT H62H rs4633 TT +/+ COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CT +/- VDR Taq rs731236 AG +/- MAO-A R297R rs6323 TT +/+ ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 AG +/- MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 GT +/- MTR A2756G rs1805087 AA -/- MTRR A66G rs1801394 GG +/+ MTRR H595Y rs10380 CC -/- MTRR K350A rs162036 AA -/- MTRR R415T rs2287780 CC -/- MTRR A664A rs1802059 GG -/- BHMT-02 rs567754 CT +/- BHMT-04 rs617219 AC +/- BHMT-08 rs651852 CT +/- AHCY-01 rs819147 CT +/- AHCY-02 rs819134 AG +/- AHCY-19 rs819171 CT +/- CBS C699T rs234706 AA +/+ CBS A360A rs1801181 GG -/- CBS N212N rs2298758 GG -/- SHMT1 C1420T rs1979277 GG -/- I am working my way slowly through this Methylation sub-forum and am finding the amount of archived information overwhelming. I did watch the Rich VanK swedish presentation which was a great intro. I am also working my way through the links in caledonia's sig and some of the posts helping other newbies by folks like Valentijn. Any suggestions on next steps, or is it best to just follow the simple Rich VanK protocol and just see how it goes? Conversely if, as asserted a few times in Rich's messages, one really should be under a Dr.'s care when embarking on this, are there Dr.'s other than Yasko folks would recommend? I think Dr. Nathan was mentioned (CA Clinic, Gordon Medical, I think worked with Rich)? What is really fantastic about Genetic Genie if you haven't looked at it lately is they now provide interpretation of your MTHFR results, and are working on the same functionality enhancement for the Detox results. However some of it is confusing. For instance it says jump on L-methylfolate supplementation for some of the issues, then says but wait, you must address CBS first. My entire diet, due to hypoglycemia, hinges on meat and eggs, so I'm not sure I can just cut out sulfur containing foods. Thanks in advance.