Phoenix Rising tells QMUL: release the PACE trial data
Mark Berry, Acting CEO of Phoenix Rising, presents the Board of Directors’ open letter to Queen Mary University of London (QMUL) urging them to release the PACE trial data, and hopes that other non-UK organisations will join British charities in the same request...
Discuss the article on the Forums.

Newton et al A Review of Hypothalamic-Pituitary-Adrenal Axis Function in CFS

Discussion in 'Latest ME/CFS Research' started by Firestormm, Oct 1, 2013.

  1. bertiedog

    bertiedog Senior Member

    South East England, UK
    I had all of the above symptoms but now that I take a full replacement amount of steroid every day ie 6mg Prednisolone I don't have any of these symptoms anymore. My case is likely to be different because I likely have a Sheehan's Syndrome which causes hypo pituitary problems but I so often recognise the symptoms that fellow ME/CFS sufferers have as pure adrenal /possible thyroid symptoms which would likely go away with the correct low dose steroid/thyroid regime which they don't get.

    Nowadays I am doing almost 6000 steps daily and yet I used to suffer in the way that you mention above. The huge problem is doctors don't recognise it just as Ema was stating.

  2. roxie60

    roxie60 Senior Member

    Central Illinois, USA
    tomorrow I find out my latest test results. Been waiting a week. Really feeling out of it tonight. I am curious what the Cortisol AM and ACTH is going to show. It was a different lab doing the tests this time because doctor wanted CD8-CD57 test and only Lab Corp available to do that so I had all the tests so not sure how they will turn out.

    I need to put together my typical list of symps, supps and synopsis of life since last visit. I cant even think clearly tonight to think about all I want to ask her......going to bed, hopefully I wont just lay there awake but will rest and this fuzzy brain will be clearer in the AM for me to put together my thoughts and plan and questions.
  3. August59

    August59 Daughters High School Graduation

    Upstate SC, USA
    I agree that the level of cortisol may not be so important, but the circadian rhythm of cortisol is extremely important. The rhythm of cortisol controls many things especially the thyroid. Without the peak of cortisol in the morning which is going to help usher more T3 into the cells and give you that wake up feeling. My cortisol is above 8 am levels from 12pm to 12 and never drops till 8 am. At 8am when it is suppose to be at it's highest, mine is lower than it is suppose to be at 12 am.
  4. peggy-sue


    If you have to get a list together, it is a good idea to keep a pen and a bit of of paper on you at all times,

    - in case something pops into your head - so you can write it down immediately, before you forget.

    Unless you are permanently attached to some computery way of having a document you can put notes in.

    In the past, I've spent up to a week compiling a list to print out and take to my gp.

    (it wasn't that long - just difficult to put together.)

    The easiest way to make your brain go blank is to "sit down" to put your list together.....:alien:
    MeSci likes this.
  5. WillowJ

    WillowJ คภภเє ɠรค๓թєl

    WA, USA
    my cortisol is not low, and I understand low cortisol is not a universal finding in us.
  6. Snow Leopard

    Snow Leopard Hibernating

    South Australia
    The standard range quoted for most regular panel tests is fairly wide, most of us will be on the low side of the standard range. This is why I insist that cortisol alone isn't really indicative of anything.

    It is a funny thing to say, but the 'statistically significant' lower cortisol levels than controls (when testing blood serum in the morning) doesn't necessarily mean that the cortisol levels of many patients will be below the quoted standard range.

    But then again statistics are often taken out of context. ;)
  7. maryb

    maryb iherb code TAK122

    can't read all of this too fogged - on recent testing my cortisol was higher than the range at all of the 4 times of the day.

See more popular forum discussions.

Share This Page