OT - discussion while we wait for news... Hi Rich, Certainly that would make sense that GD is somewhere in the CFS brain pathologies. So following that logic, given that the hypothalamus is partly inside the BBB (the emitters and a few receptor neurons are outside), perhaps nature designed that system to expect fewer insults. Then when the BBB gets compromised (by co-infections perhaps), the hypothalamus loses GSH and becomes sluggish. Hmmm. I like that model, very elegant. Simple yet could theoretically account for pretty much every major part of CFS. And if the Hypothalamus had low GSH and functioned sluggishly one would expect it to become easily overwhelmed by any type of ordinary input. Here is a nice summary of those inputs: http://thalamus.wustl.edu/course/hypoANS.html So many top CFS researchers and practitioners seem to have danced around this type of model for CFS. And certainly multiple co-infections, including persistent retroviral forms, could be depleting GSH in the brain and thus altering functions of the hypothalamus. Wasn't there a study though that found GSH levels normal in the brains of PWC? I wonder if they looked at the hypothalamus, that organ is particularly susceptible probably, given it is both inside and outside the BBB.