Hi,
New to the forum.
I have invested in my Acumen's translocator protein studies, ATP studies and DNA adducts tests recently. If anyone could help interpret the results I'd really appreciate it, particularly with ref to supplementation, and what these results actually mean - Im looking at upping my Mg intake to include 150mg per day as a chelated form (glycinate)
I also currently supplement with 1 x Adrenomax per day and 10ug Vitamin D, and 1x probiotic ( plantarum LP229v)
I had dental amalgams removed in 2006.
I had a urine analysis in 2008 which indicated pyroluria/ high kryptopyrolles.
I worked in an industrial chemical lab for 25yrs so I guess on balance its maybe not that bad.
My symptoms are relatively mild thankfully, but what I do know is that if I drop the Adrenomax I start to have more severe problems so it seems to be providing something I need (maybe the Mg)
What Id also like to know is if these tests have been carried out on normal people (by way of a control) and what were the results?
Here are the results:
Initial Examination
---------------------
mitochondria numbers of: normal
mitochondrial clumping: normal
mt-membrane structure: normal
mt-DNA fluorescence: normal
Mt-Membrane Binding
-----------------------
proteins: normal
esterases: normal
lipids: normal
Diolein: ND
Aldehydes: Trace
Chemical on TL sites
------------------------
Benzoquinone: high
Mercury: trace only
Other
----------
Mt membrane K: normal
Mt membrane Mg: low
Mt membrane Zn: low-norm
ATP (adenosine triphosphate), studies on neutrophils
ATP whole cells:
With excess Mg added 1.29 nmol/10 6 cells (range 1.6-2.9)
Endogenous Mg only 0.78 nmol/10 6 cells (range 0.9-2.7)
Ratio ATP/ATP Mg 0.6 (range >0.65)
ADP to ATP conversion efficiency (whole cells)
ATP from above :1.29 (units as above) (range 1.6 -2.9)
ATP Mg (inhibitor present) : 0.35 (range <0.3)
ATP Mg (inhibitor removed) :0.81 (range >1.4)
ADP to ATP efficiency = 48.9% (range >60)
Blocking of active sites = 27.1% (range :up to 14)
Comments
Very low whole cell ATP
Low ATP related Magnesium
27.1% block of active sites leading to: Very low ADP to ATP re-conversion
Restricted access, 27.1% blocked translocator function
DNA ADDUCTS (genomic DNA from leucocytes)
Total DNA (from 1ml whole blood) = 48 ug (reference 30-60)
Adduct Found ng/ml blood gene (if identified)
Hydroquinone#1 3 Non gene area, q12
Benzoquinone #2 1 Glutamine synthease #3
DNA-associated zinc= 24ng/ml (reference 21-74)
Thanks a lot
Andy.
New to the forum.
I have invested in my Acumen's translocator protein studies, ATP studies and DNA adducts tests recently. If anyone could help interpret the results I'd really appreciate it, particularly with ref to supplementation, and what these results actually mean - Im looking at upping my Mg intake to include 150mg per day as a chelated form (glycinate)
I also currently supplement with 1 x Adrenomax per day and 10ug Vitamin D, and 1x probiotic ( plantarum LP229v)
I had dental amalgams removed in 2006.
I had a urine analysis in 2008 which indicated pyroluria/ high kryptopyrolles.
I worked in an industrial chemical lab for 25yrs so I guess on balance its maybe not that bad.
My symptoms are relatively mild thankfully, but what I do know is that if I drop the Adrenomax I start to have more severe problems so it seems to be providing something I need (maybe the Mg)
What Id also like to know is if these tests have been carried out on normal people (by way of a control) and what were the results?
Here are the results:
Initial Examination
---------------------
mitochondria numbers of: normal
mitochondrial clumping: normal
mt-membrane structure: normal
mt-DNA fluorescence: normal
Mt-Membrane Binding
-----------------------
proteins: normal
esterases: normal
lipids: normal
Diolein: ND
Aldehydes: Trace
Chemical on TL sites
------------------------
Benzoquinone: high
Mercury: trace only
Other
----------
Mt membrane K: normal
Mt membrane Mg: low
Mt membrane Zn: low-norm
ATP (adenosine triphosphate), studies on neutrophils
ATP whole cells:
With excess Mg added 1.29 nmol/10 6 cells (range 1.6-2.9)
Endogenous Mg only 0.78 nmol/10 6 cells (range 0.9-2.7)
Ratio ATP/ATP Mg 0.6 (range >0.65)
ADP to ATP conversion efficiency (whole cells)
ATP from above :1.29 (units as above) (range 1.6 -2.9)
ATP Mg (inhibitor present) : 0.35 (range <0.3)
ATP Mg (inhibitor removed) :0.81 (range >1.4)
ADP to ATP efficiency = 48.9% (range >60)
Blocking of active sites = 27.1% (range :up to 14)
Comments
Very low whole cell ATP
Low ATP related Magnesium
27.1% block of active sites leading to: Very low ADP to ATP re-conversion
Restricted access, 27.1% blocked translocator function
DNA ADDUCTS (genomic DNA from leucocytes)
Total DNA (from 1ml whole blood) = 48 ug (reference 30-60)
Adduct Found ng/ml blood gene (if identified)
Hydroquinone#1 3 Non gene area, q12
Benzoquinone #2 1 Glutamine synthease #3
DNA-associated zinc= 24ng/ml (reference 21-74)
Thanks a lot
Andy.