Thanks Bob. Lots of similarities in our history there. I also no longer get full blown depressions, with ME its more like a series of much milder and shorter lasting low periods that occur randomly...almost as if a depression has been chopped into timy pieces and fed through my brain it little bits over the period of a few years. Psychiatrists always said my clinical depression is caused by having a genetically-linked natural reduction in the appropriate level of neurotransmitters (serotonin/norepinephrine)in certain parts of my brain. However, now having had ME for 12 yrs (since my mid 20s), i would hazzard an experienced guess that my depressions were more likely caused by temporary blockages to the blood supply in those certain parts of the brain, those blockages being formed by neuroimmune-activated inflammation. If i am found to be XMRV positive i would also expect to have had it from birth.