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New Theory Links Depression to Chronic Brain Inflammation

Discussion in 'Other Health News and Research' started by guest, Oct 21, 2010.

  1. Angela Kennedy

    Angela Kennedy *****

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    Essex, UK
    Sickness behaviour because of somatic illness is one thing, and ubiquitous to ALL organic illnesses. It's when special pleading is done with CFS as an 'unexplained' (therefore given psychogenic explanation by default) illness that we run into problems. THIS is what the CDC have been doing! They're claiming infections are 'triggers' rather than causational (and not researching into infectious causation, even where the evidence should point them in that direction) and 'stress' or other psychogenic explanation is almost (perhaps even) always resorted to.

    And, this study above has used unsubstantiable psychogenic causation theory. That makes it problematic, and most likely useless towards researching or theorising Canadian defined ME/CFS.
  2. D Bergy

    D Bergy

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    Yes, the resolution of my depression symptoms were due to using higher doses of anti-inflammatory supplements.

    I use double the normal Krill Oil dosage, and two 1500 mg doses of Turmeric and Ginger capsules daily.

    I also worked on removing pathogens from the intestinal tract, and went on Low Dose Naltrexone to boost my immune system. Later on I was able to lower my supplement dosages, as I apparently had reduced the pathogens causing the inflammation, and the LDN probably helped control this also.

    There are reasons for the inflammation, and it likely involves a pathogen, or multiple pathogens. I have deduced what some of mine are, and actively try to reduce them, any way I can.

    Dan
  3. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Just curious Cort, how do you/we know that whomever you talked to at the CDC was not just blowing smoke, you know where? the CDC seems like a lost cause to me, time will tell with Dr. Unger, but I think you are correct when you mentioned that the NIH has dropped the ball with our condition!

    GG
  4. WillowJ

    WillowJ Senior Member

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    WA, USA
    I realize that CDC uses that phrase a lot and that most scientists use this to refer to lab animals who are displaying signs of infection (and whom they cannot question about symptoms and receive an intelligible reply, say in English--as far as I'm aware, this phrase is not otherwise normally used for humans, who would normally be expected to be capable of telling you about their symptoms intelligibly), but in the CDC's case, I'm pretty sure it's a code phrase for "escape-avoidant behaviour" (use of the extra u is deliberate and should be interpreted accordingly). It's not an accident that they say "mind-body disorder."

    While Dr. Elizabeth Unger may find herself in an untenable situation, being pressured to say things she may not believe or may not fully believe (mind-body disorder, psychosomatic disorder) in order to try to maintain the pretense of some shred of credibility for her employer, she isn't being held at gunpoint, either. Whistleblower, for instance, is a viable option for her.

    The CDC's position flies in the face of overwhelming evidence against all of its key positions, and as soon as NIH's website goes online this will be obvious to everyone (not only to those few of us who have a strong need to care about it and thus do the research).

    Unger doesn't have to toe the line.
  5. dancer

    dancer Senior Member

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    Anyone have a clue about WHEN the updated NIH website on ME/CFS will come on line? I check back to the NIH site frequently, and am weary of the "website currently under construction" message. I'd LOVE something to point my doctor to.
  6. Cort

    Cort Phoenix Rising Founder

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    This is I did not know.. although it certainly makes sense. I guess there are no biomarkers for depression! If there were I guess it would be treated as a more physical illness although the increased focus on pharmaceuticals seems to suggest that they are treating it that way (???)
  7. Cort

    Cort Phoenix Rising Founder

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    Actually that was not a good statement from me...The CDC is not interested in the infectious cause of CFS; it has shown signs in the literature it focuses on that it is interested in the cytokine theory of CFS; that is where the Emory group comes in - some of the authors there have focused on that aspect, altho not in the CFS. Nor has the CDC show any signs in its research, which is where the rubber meets the road, that it is exploring a cytokine theory of CFS. My apologies for being unclear.

    Their focus now appears to be on linking cortisol abnormalites to early life stresses including infection I believe - but heretofore on sexual abuse, personality problems and things like that. Whether Unger will take that road we will see. That is not her background - but we shall if she makes any changes. I sincerely hope that she does.
  8. Cort

    Cort Phoenix Rising Founder

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    'Sickness behavior' is a specific term applied to the flu-like symptoms produced during infections although, according to Wikidpedia researchers are now considering whether depression may fit the bill as well. In any case - it has been proven to be associated with immune activity - specifically some cytokines. Despite its weird name it is not a psychological but a physiological theory of disease that have been pretty well charted out thus far. Depression is now being considered because of the recognition that cytokines and other inflammatory agents may play a major role in causing 'it' -whatever it is :).

  9. Cort

    Cort Phoenix Rising Founder

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    Here's from a review of "Sickness Behavior" by the leading researcher in the field. It's interesting that he focuses on the 'innate' immune system since that is the system which includes NK cells, monocytes/macrophages -which appears to be most messed up in CFS.

    Immunol Allergy Clin North Am. 2009 May; 29(2): 247264.

    Cytokine, Sickness Behavior, and Depression
    Robert Dantzer, DVM, Ph
    D

  10. WillowJ

    WillowJ Senior Member

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    hmm, the use of the term does seem to be broader than I was aware.

    However, it doesn't exempt anyone from mind-body disorder (although they listed CFS in the correct location here :cool:)

    http://www.highbeam.com/doc/1G1-169493417.html (full article not available without signing up, but several paragraphs are viewable)
    so it doesn't stop ppl from theories like this

    from CFS to "sickness syndrome", hmm.

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