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New Swedish ME/CFS-study indicates autoimmunity

Discussion in 'Latest ME/CFS Research' started by Ninan, Dec 11, 2013.

  1. Bob

    Bob

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    South of England
  2. Bob

    Bob

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    Just adding the title of the PlosOne study so I can find this thread in future, using the search facility (it's not included anywhere in this thread):

    Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis
     
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  3. Simon

    Simon

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    Monmouth, UK
    From Tate Mitchell via co-cure

    Looks like a translation of an original pience in Norwegian - not sure who wrote the original
    http://translate.google.com/transla...sala/nya-ron-om-kronisk-trotthet-2787943.aspx

    New findings on chronic fatigue

    It is common for patients with chronic fatigue syndrome have
    antibodies in their blood that target a protein found in both human
    cells and bacteria.

    It appears from a study published in the prestigious science journal PLoS ONE.

    - Because healthy people rarely or never have the kind of antibodies
    supports our results the theory that chronic fatigue syndrome in at
    least some cases may be a so-called autoimmune disease triggered by a
    common infection, says Jonas Blomberg, professor of virology at the
    University of Uppsala.

    In the study, the researchers synthetically produced smaller parts,
    called peptides, a protein called HSP60. HSP60 protein was found both
    in the cells' "power plants", mitochondria, multicellular organisms
    like ourselves and in bacteria.

    - We know from experience that it is common for patients with
    diabetes, multiple sclerosis and other autoimmune diseases have
    antibodies in their blood that target any part of the HSP60 protein,
    says Jonas Blomberg.

    With the help of the derived peptides, the researchers have now for
    the first time investigated whether also patients with chronic fatigue
    syndrome have antibodies in their blood against any part of the HSP60
    protein. The answer was yes.

    Of the 69 blood samples from patients with chronic fatigue syndrome
    contained 17, that is, almost every fourth sample, antibodies against
    a peptide present in the HSP60 protein in a bacterium that can cause
    troublesome respiratory infections, chlamydia pneumoniae. However,
    only one of the samples from 331 healthy blood donors and 68 patients
    with either of the two autoimmune diseases multiple sclerosis and SLE
    which contained antibodies to this particular peptide.

    - A hypothesis on the basis of our findings is that antibodies
    generated in response to an infection may contribute to the symptoms
    of chronic fatigue syndrome by disrupting the endogenous HSP60
    protein's normal functions in mitochondria. However, this is something
    that needs to be further explored in future studies, says Jonas
    Blomberg.


    Researchers at Uppsala have conducted the study in collaboration with
    colleagues at Gottfries Clinic in Mölndal and a research center in
    Heidelberg in Germany.

    By: Ake Spross ake.spross @ unt.se 018-4781312
     
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  4. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    aimossy, Esther12, Bob and 1 other person like this.
  5. Helen

    Helen Senior Member

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    It is a translation from a Swedish local daily paper written by a journalist. As you might remember Prof. Jonas Blomberg a.o. conducted the replicating study of the XMRV virus http://www.ncbi.nlm.nih.gov/pubmed/22787191.
    The actual study was lead by him too, in the city where the article was published.
     
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  6. Kate_UK

    Kate_UK Senior Member

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    alex3619 and justy like this.

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