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New study - prospects for the treatment of retroviral diseases

Discussion in 'XMRV Research and Replication Studies' started by natasa778, Feb 10, 2010.

  1. @Eric, Please please PM the text to _Kim_ so she can add it to our private library here. You're an absolute gem and managed to explain this so well so that even a brain-fogged arts graduate can understand it ;)

    Gerwyn and Natasa... hats off to you to for making this all possible.

    Rachel xx
  2. Gerwyn

    Gerwyn Guest

    I wonder if it would be possible to transpose retroviral gene silencing suppressor analogues using xmrv intergegrase as the base sequence
  3. omerbasket

    omerbasket Senior Member

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    I didn't understand exactly what you mean, Gerwyn (becuase I'm not a scientist), but I think that perhaps my following questions would be similar to your message. My questions for the people who knows science here are:
    1) Do you think it might be possible that if you give someone who is already XMRV positive a shot which contains XMRV viruses (perhaps weakened viruses) but without the potent immunosuppressive domain which this study found in the virus envelope - would be able to teach this someone's body how to kill XMRV and there for might teach his body how to kill the regular XMRV, which has already been in his body and have this potent immunosuppressive domain?
    2) Do you think that giving someone a shot of this potent immunosuppressive domain alone (without the rest of the virus), perhaps in some weakened version might teach the body how to deal with it, and therefore teach the body how to kill the XMRV that is also in the body?
    3) Do you think that giving someone a shot of a weakned XMRV, containing a weakened version of this potent immunosuppressive domain, might teach the body how to kill the XMRV that is already in the body?
    4) Do you think that this discovery might open a promising door for vaccines for those who don't have this retroviruses in their body?

    I would be happy if even in case in which you write your answer in scientific words, you would try to give a bottom line in a language that we would all understand (if it's possible).

    Thanks!
  4. Gerwyn

    Gerwyn Guest

    There are certain vaccines that only contain bits of the virus sufficient for the bodies immune system to react to at a subclinical level.the immune system then retains a memory of this bit of the virus so when the whole thing infects the immune system"is lying in wait" for it.So if the sequence in the env protein is big enough to be recognised as foreign by the immune system you could theoretically construct a vaccine

    answer to 2 and 4 yes in theory

    I and 2 no I dont think so The virus titres(no of virus particles) are low so most of the virus appears to be hiding in the host DNA where it seems to cause most of the damage . It seems to be doing something to the neighbouring bits of DNA which in turn dont do what they should. Somewhere in our history we developed a special defence against retroviruses in particular called gene silencing . The dna sequences either side of the integrated viruses "switch off" to stop the viruses hijacking our DNA to replicate itself.Retroviruses in turn have adapted to produce gene silencing suppressor sequencesuch as AIDS.XMRV may actually have adapted to make use of this natural gene silencing leading to an underexpression of genes needed for the immune system to work properly.My suggestion was to introduce an artificial analogue to stop this gene silencing and get the immune system working properly again----This is theoretical---a way of explaining why xmrv can damage the immune system without coding for any destructive proteins
  5. Eric Johnson from I&I

    Eric Johnson from I&I Senior Member

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    1. plausible 2. naw 3. plausible 4. plausible
  6. Gerwyn

    Gerwyn Guest

    4 the most likely subunit vaccines are quite successful 2 possible competitor activity might inhibit immunosuppression ability of Wt base sequence still think 1 and 3 no as most virus latent if studies are correct!
  7. omerbasket

    omerbasket Senior Member

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    Thanks Gerwyn and Eric, once again!
  8. Rrrr

    Rrrr Senior Member

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    bumping this thread, because it is so freaking good.

    rrrr

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