BeautifulDay
Senior Member
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New study: “UCLA Researchers Find New Link Between Damaged Mitochondria and Age-related Diseases”. https://mitochondrialdiseasenews.co...ail&utm_term=0_fdcf314ce5-05476bb628-72147965
From the article -- “UCLA researchers showed that by promoting the expression of Drp1 in middle-aged flies, cells were able to discard damaged mitochondria, keeping only the healthy mitochondria. This made the flies healthier and more energetic, while prolonging their lives”
The protein Drp1 (dynamin-related protein 1) is encoded by the DNM1L gene. This is interesting. In looking at this gene from the view of in promoting that gene can make mitochondria more healthy, then the reverse would likely also be true. If a pathogenic mutation were to be found in the Drp1 gene, then could it cause Mitochondrial Disease.
Take a trip over to the Mitochondrial Disease mutation database to see if the DNM1L gene is in the database.
https://mseqdr.org/mb.php?url=genes.php
Under “Symbol” eter DNM1L and push enter.
Click on “dynamin 1-like”.
Page down and click on “transcript variant 5”.
Click on “c.1223C>A”
Up pops genomic variant rs121908531 which is pathogenic for “Encephalopathy due to defective mitochondrial and peroxisomal fission 1”.
23andme did not report rs121908531 for anyone in our family. I wasn’t thinking we had the gene, it’s just interesting to see what 23andme has tested for and what it hasn’t and what is hidden behind internal numbers.
Well anyway, this is just another avenue of hope – speed up the production of good mitochondria and get rid of the malfunctioning mitochondria quicker. I’ve seen several scientific articles written on this same subject from the standpoint of different genes and different proteins. All very interesting.
From the article -- “UCLA researchers showed that by promoting the expression of Drp1 in middle-aged flies, cells were able to discard damaged mitochondria, keeping only the healthy mitochondria. This made the flies healthier and more energetic, while prolonging their lives”
The protein Drp1 (dynamin-related protein 1) is encoded by the DNM1L gene. This is interesting. In looking at this gene from the view of in promoting that gene can make mitochondria more healthy, then the reverse would likely also be true. If a pathogenic mutation were to be found in the Drp1 gene, then could it cause Mitochondrial Disease.
Take a trip over to the Mitochondrial Disease mutation database to see if the DNM1L gene is in the database.
https://mseqdr.org/mb.php?url=genes.php
Under “Symbol” eter DNM1L and push enter.
Click on “dynamin 1-like”.
Page down and click on “transcript variant 5”.
Click on “c.1223C>A”
Up pops genomic variant rs121908531 which is pathogenic for “Encephalopathy due to defective mitochondrial and peroxisomal fission 1”.
23andme did not report rs121908531 for anyone in our family. I wasn’t thinking we had the gene, it’s just interesting to see what 23andme has tested for and what it hasn’t and what is hidden behind internal numbers.
Well anyway, this is just another avenue of hope – speed up the production of good mitochondria and get rid of the malfunctioning mitochondria quicker. I’ve seen several scientific articles written on this same subject from the standpoint of different genes and different proteins. All very interesting.
